2-[4-(1,3-二恶烷-2-基)苯基]乙醇合成路线 （共 4 条）
反应条件
toluene-4-sulfonic acid in toluene 1 h; Heating;
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
1: 98 percent / p-toluenesulfonic acid / CH2Cl2 / 2 h / 0 °C 2: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 1 h, 2.) hexane, THF, -78 deg C, 1.5 h 3: 1 M aq. HCl / acetone / 1.5 h / 5 °C 4: 68 percent / p-toluenesulfonic acid / toluene / 1 h / Heating View Scheme
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 1 h, 2.) hexane, THF, -78 deg C, 1.5 h 2: 1 M aq. HCl / acetone / 1.5 h / 5 °C 3: 68 percent / p-toluenesulfonic acid / toluene / 1 h / Heating View Scheme
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
1: 1 M aq. HCl / acetone / 1.5 h / 5 °C 2: 68 percent / p-toluenesulfonic acid / toluene / 1 h / Heating View Scheme
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
