1: 2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidine-1-carboxylic acid tert-butyl ester With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: allyl bromide in N,N-dimethyl-formamide T=0 - 20°C; 2 h;

1.1: 93 percent / 4-DMAP / acetonitrile / 4 h / 20 °C 2.1: NaH / dimethylformamide / 0.5 h / 0 °C 2.2: 15 percent / dimethylformamide / 2 h / 0 - 20 °C View Scheme