1-Boc-4-(4-溴苯基)-哌啶-4-醇合成路线 （共 7 条）
参考文献
Wu, Wen-Lian; Burnett, Duane A.; Spring, Richard; Qiang, Li; Sasikumar, Thavalakulamgara K.; Domalski, Martin S.; Greenlee, William J.; O'Neill, Kim; Hawes, Brian E.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3668 - 3673
反应条件
1: 4-bromo-1-iodobenzene With n-butyllithium in tetrahydrofuran T=-78°C; 2.5 h; Inert atmosphere; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere;
参考文献
Oslob, Johan D.; Johnson, Russell J.; Cai, Haiying; Feng, Shirley Q.; Hu, Lily; Kosaka, Yuko; Lai, Julie; Sivaraja, Mohanram; Tep, Samnang; Yang, Hanbiao; Zaharia, Cristiana A.; Evanchik, Marc J.; McDowell, Robert S.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 1 p. 113 - 117
反应条件
1: p-bromophenyl bromide With n-butyllithium in tetrahydrofuran; hexane T=-78 - -20°C; 1 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran; hexane T=-78°C; 1 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/156739 A1, 2008 ;
Location in patent: Page/Page column 226 ;
WO 2008/156739 A1
参考文献
Chen, Gang; Xia, Hongguang; Cai, Yu; Ma, Dawei; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 234 - 239
反应条件
1: HCl; AcOH 2: HCl 3: NaOH View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 80 °C / |Inert atmosphere 2: trichlorophosphate / pyridine / 20 °C / |Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C View Scheme
参考文献
Oslob, Johan D.; Johnson, Russell J.; Cai, Haiying; Feng, Shirley Q.; Hu, Lily; Kosaka, Yuko; Lai, Julie; Sivaraja, Mohanram; Tep, Samnang; Yang, Hanbiao; Zaharia, Cristiana A.; Evanchik, Marc J.; McDowell, Robert S.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 1 p. 113 - 117
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 80 °C / |Inert atmosphere 2: trichlorophosphate / pyridine / 20 °C / |Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C 4: hydrogenchloride / ethyl acetate / 1 h / 20 °C View Scheme
参考文献
Oslob, Johan D.; Johnson, Russell J.; Cai, Haiying; Feng, Shirley Q.; Hu, Lily; Kosaka, Yuko; Lai, Julie; Sivaraja, Mohanram; Tep, Samnang; Yang, Hanbiao; Zaharia, Cristiana A.; Evanchik, Marc J.; McDowell, Robert S.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 1 p. 113 - 117
