2',3',5'-三-O-乙酰-2-氨基-6-氯嘌呤核苷合成路线 （共 36 条）
反应条件
tetraethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate in acetonitrile T=80°C;
参考文献
Kamaike; Kinoshita; Niwa; Hirose; Suzuki; Ishido
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 1-2 p. 59 - 75
反应条件
pyridine in N,N-dimethyl-formamide T=80°C; 2 h;
参考文献
Ohno, Michihiro; Gao, Zhan-Guo; Van Rompaey, Philippe; Tchilibon, Susanna; Kim, Soo-Kyung; Harris, Brian A.; Gross, Ariel S.; Duong, Heng T.; Van Calenbergh, Serge; Jacobson, Kenneth A.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2995 - 3007
反应条件
1: DMAP; Et3N / acetonitrile 2: POCl3; N,N-diethylaniline View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 717 - 720
反应条件
trimethylsilyl trifluoromethanesulfonate; bovine serum albumin in dichloromethane T=80°C;
参考文献
Chinese Journal of Chemistry, , vol. 31, # 9 p. 1207 - 1218
反应条件
1: 92 percent / Bu4NIO4; RuCl3 / CH2Cl2; acetonitrile; H2O / 0.5 h / 20 °C 2: 96 percent / DBU / acetonitrile / 1 h / 20 °C 3: 99 percent / Et4NCl; N,N-dimethylaniline; POCl3 / acetonitrile / 80 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 1-2 p. 59 - 75
反应条件
1: 96 percent / DBU / acetonitrile / 1 h / 20 °C 2: 99 percent / Et4NCl; N,N-dimethylaniline; POCl3 / acetonitrile / 80 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 1-2 p. 59 - 75
反应条件
1.1: hydrazine hydrate; AcOH; pyridine / 0.5 h / 20 °C 1.2: 96 percent / pyridine / 1 h / 20 °C 2.1: 92 percent / Bu4NIO4; RuCl3 / CH2Cl2; acetonitrile; H2O / 0.5 h / 20 °C 3.1: 96 percent / DBU / acetonitrile / 1 h / 20 °C 4.1: 99 percent / Et4NCl; N,N-dimethylaniline; POCl3 / acetonitrile / 80 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 1-2 p. 59 - 75
反应条件
N,N-dimethyl-aniline; trichlorophosphate Yield given. Multistep reaction;
参考文献
Synthesis, , # 6 p. 450 - 453
反应条件
1: 84 percent / (C2H5)3N / tetrahydrofuran / 17 h / 25 °C / Irradiation 2: 96 percent / NH3(g) / ethanol / 23 h / 25 °C View Scheme
参考文献
Nair; Young; DeSilvia Jr.
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1344 - 1347
反应条件
diiodomethane; iodine; isopentyl nitrite; copper(l) iodide in tetrahydrofuran 0.75 h; Heating;
参考文献
Gruenewald, Christian; Kwon, Taewoo; Piton, Nelly; Foerster, Ute; Wachtveitl, Josef; Engels, Joachim W.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 1 p. 19 - 26
