2',3',5'-三-O-乙酰-2-氨基-6-氯嘌呤核苷合成路线 （共 36 条）
反应条件
1: 82 percent / sodium nitrite; dichloroacetic acid / tetrahydrofuran 2: 61 percent / NH3 / methanol / -5 - 0 °C View Scheme
参考文献
Francom, Paula; Janeba, Zlatko; Shibuya, Susumu; Robins, Morris J.
Journal of Organic Chemistry, 2002 , vol. 67, # 19 p. 6788 - 6796
反应条件
chloro-trimethyl-silane; BnEt3NNO2; sodium nitrite in dichloromethane T=20°C; 1 h;
参考文献
Francom, Paula; Robins, Morris J.
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 666 - 669
反应条件
chloro-trimethyl-silane; tert.-butylnitrite; 1,1-dibromomethane T=20°C; 3 h;
参考文献
Journal of Organic Chemistry, , vol. 68, # 2 p. 666 - 669
反应条件
1: BnEt3NNO2; acetyl chloride / dichloromethane / 1 h / 0 °C / |Inert atmosphere; |Cooling with ice 2: ammonia / ethanol / 72 h / 20 °C 3: NH2NH2•xH2O / 10 h / 20 °C View Scheme
参考文献
El-Tayeb, Ali; Gollos, Sabrina
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447
反应条件
1: Ph3CCl, K2CO3, isoamyl nitrite / CH2Cl2 / 0.5 h / Heating 2: conc. NH4OH / tetrahydrofuran / 72 h / Ambient temperature View Scheme
参考文献
El-Tayeb, Ali; Gollos, Sabrina
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447
参考文献
Ubiali, Daniela; Serra, Carla D.; Serra, Immacolata; Morelli, Carlo F.; Terreni, Marco; Albertini, Alessandra M.; Manitto, Paolo; Speranzab, Giovanna
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 1 p. 96 - 104
反应条件
ammonia T=-80 - 70°C; 16 h;
参考文献
Volpini, Rosaria; Marucci, Gabriella; Buccioni, Michela; DalBen, Diego; Lambertucci, Catia; Lammi, Carmen; Mishra, Ram C.; Thomas, Ajiroghene; Cristalli, Gloria
ChemMedChem, 2011 , vol. 6, # 6 p. 1074 - 1080
反应条件
triethylamine in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
Divakar, K. J.; Mottahedeh, Mina; Reese, Colin B.; Sanghvi, Yogesh S.; Swift, Karl A. D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 4 p. 771 - 774
反应条件
potassium fluoride; trimethylamine in N,N-dimethyl-formamide 14 h; Ambient temperature;
参考文献
Robins; Uznanski
Canadian Journal of Chemistry, 1981 , vol. 59, # 17 p. 2601 - 2607
反应条件
copper(l) iodide; diiodomethane; iodine; isopentyl nitrite T=80°C; 0.25 h;
参考文献
Matsuda; Shinozaki; Yamaguchi; Homma; Nomoto; Miyasaka; Watanabe; Abiru
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 241 - 252
