2',3',5'-三-O-乙酰-2-氨基-6-氯嘌呤核苷合成路线 （共 36 条）
反应条件
1: 83 percent / n-pentyl nitrite, diiodomethane / 2 h / 80 °C 2: 93 percent / NH3 / ethanol / 23 h / 25 °C 3: 55 percent / H2O / 7.5 h / Irradiation View Scheme
参考文献
Divakar, K. J.; Mottahedeh, Mina; Reese, Colin B.; Sanghvi, Yogesh S.; Swift, Karl A. D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 4 p. 771 - 774
反应条件
tert.-butylnitrite; water; isopropyl alcohol T=15 - 20°C; Product distribution / selectivity;
参考文献
Moorman, Allan R.
Patent: US2003/199686 A1, 2003 ;
Location in patent: Page/Page column 6 ;
反应条件
1: NH3 / methanol 2: phenylmethanol 3: sodium nitrite; HBF4 / H2O 4: methanol 5: H2 / Pd/C View Scheme
参考文献
Cheng, Bernice; McClelland, Robert A.
Canadian Journal of Chemistry, 2001 , vol. 79, # 12 p. 1881 - 1886
反应条件
1: 81 percent / triethylamine / methanol / 4 h / Ambient temperature
2: 89 percent / phenol, boron trifluoride diethyl etherate / CH2Cl2 / 2 h / Heating
3: ammonium sulfate / 3 h / Heating
4: mercury(II) cyanide / benzene / 2 h / Heating
5: 94 percent / hydrazine monohydrate / ethanol / 18 h / Heating
6: 70 percent / yellow mercury(II) oxide / 2-methoxy-ethanol / 2 h / 80 °C
View Scheme
参考文献
Buck, Ildiko M.; Eleuteri, Alessandra; Reese, Colin B.
Tetrahedron, 1994 , vol. 50, # 30 p. 9195 - 9206
反应条件
1: 63 percent / isoamyl nitrite, CH2I2 / 0.42 h / 80 °C / Heating
2: 90 percent / methanolic ammonia / 17 h / 60 °C
3: 84 percent / CuI, bis(triphenylphosphine)palladium dichloride, Et3N / dimethylformamide / 1 h / 80 °C
View Scheme
参考文献
Matsuda; Shinozaki; Yamaguchi; Homma; Nomoto; Miyasaka; Watanabe; Abiru
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 241 - 252
反应条件
1: 83 percent / n-pentyl nitrite, diiodomethane / 2 h / 80 °C
2: 93 percent / NH3 / ethanol / 23 h / 25 °C
3: 84 percent / pyridine / 1.) 0 deg C, 1 h, 2.) 25 deg C, 2 h
4: 51 percent / n-pentyl nitrite, diiodomethane / 7 h / 80 °C
View Scheme
参考文献
Nair; Young
Journal of Organic Chemistry, 1985 , vol. 50, # 3 p. 406 - 408
