2-[2-(4-氟苯基)-2-氧代-1-苯基-乙基]-4-甲基-3-氧代-戊酸,(4-苄氧基-苯基)-酰胺合成路线 （共 6 条）
反应条件
3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine in ethanol T=90 - 110°C; 12 h;
参考文献
AMBIT BIOSCIENCES CORPORATION
Patent: WO2006/110918 A1, 2006 ;
Location in patent: Page/Page column 58 ;
反应条件
triethylamine in ethanol; hexane; 4-fluorobenzaldehyde; ethyl acetate
参考文献
Warner-Lambert Company
Patent: US5385929 A1, 1995 ;
反应条件
1: 82 percent / toluene / Heating 2: β-alanine; glacial acetic acid / hexane / Heating 3: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating View Scheme
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270
反应条件
1: β-alanine; glacial acetic acid / hexane / Heating 2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating View Scheme
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270
反应条件
1: pivalic acid / tetrahydrofuran; toluene; heptane / Heating 2: 85 percent / hydrogen; acetic acid / palladium on carbon / ethyl acetate / 34 h / 2585.74 Torr View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 3 p. 261 - 270
反应条件
2,2,2-trimethylacetic acid in tetrahydrofuran; n-heptane; toluene Cycloaddition; condensation; Heating;
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270
