2,2,2-三氯-1-(1H-吡咯并[2,3-b]吡啶-3-基)-乙酮合成路线 （共 4 条）
反应条件
AlCl3, aluminium chloride in dichloromethane T=20°C; 2.5 - 6 h; Product distribution / selectivity;
参考文献
SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.
Patent: WO2008/5457 A2, 2008 ;
Location in patent: Page/Page column 69; 93 ;
WO 2008/005457 A2
反应条件
triethylamine T=20°C; 2 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/28475 A2, 2005 ;
Location in patent: Page/Page column 131-132 ;
WO 2005/028475 A2
反应条件
1: With potassium hydroxide in water 2 h; 2: With hydrogenchloride in water pH=2;
参考文献
SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.
Patent: WO2008/5457 A2, 2008 ;
Location in patent: Page/Page column 73 ;
WO 2008/005457 A2
反应条件
ammonia in 1,4-dioxane
T=80°C; 72 h;
参考文献
SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.
Patent: WO2008/5457 A2, 2008 ;
Location in patent: Page/Page column 69 ;
WO 2008/005457 A2
