反应条件
1.1: methanesulfonic acid / acetone / 2 h / 20 °C 2.1: toluene / 72 h / |Reflux 3.1: potassium iodide; chloro-trimethyl-silane / acetonitrile / 0.58 h / 20 °C 4.1: chloro-trimethyl-silane; 1H-imidazole / dichloromethane / 0.5 h / 20 °C 4.2: 0.25 h / 20 °C 5.1: lithium hydroxide hydrate / tetrahydrofuran; water / 18 h 6.1: triphenylphosphine; di-isopropyl azodicarboxylate / 3 h / 0 °C 7.1: 1,1-dimethylethylmagnesium chloride / diethyl ether / 2 h / 0 °C 8.1: hydrogen; palladium 10 on activated carbon / ethyl acetate; methanol / 18 h / 750.08 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 14 p. 7048 - 7057
