1.1: pyridine / dichloromethane / 1 h / 0 °C 1.2: 12 h / Cooling 2.1: copper (I) cyanide / tetrahydrofuran / 1 h / 0 °C 3.1: 3,3-dimethyldioxirane / acetone / 4 h / 0 °C 4.1: ammonia / methanol / 0.5 h / 100 °C / Microwave 5.1: triethylamine / N,N-dimethyl-formamide / 60 °C 6.1: trifluoroacetic anhydride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C 6.2: 0.5 h 7.1: trifluoroacetic acid; pyridine / toluene / 0.5 h / 0 °C 7.2: 20 h / 15 °C 8.1: ammonia / isopropyl alcohol; water / 20 h / 100 °C / 31029.7 Torr 9.1: hydrogenchloride / methanol / 2 h / 65 °C View Scheme

1: 63 percent / triphenylphosphine; diisopropyl diazodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C 2: 89 percent / trifluoroacetic acid / 4 h / 20 °C View Scheme