4-甲氨基-3-硝基吡啶合成路线 （共 18 条）
反应条件
hydrogen trioxochlorate(V); tin(ll) chloride in water T=90°C; 3 h; Heating / reflux;
参考文献
ALTANA PHARMA AG
Patent: WO2005/26164 A1, 2005 ;
Location in patent: Page/Page column 42 ;
反应条件
hydrogenchloride; NaH; stannous chloride in N-methyl-acetamide
参考文献
Merck Patent Gesellschaft Mit Beschrankter Haftung
Patent: US4654350 A1, 1987 ;
反应条件
in methanol; ammonium hydroxide; water
参考文献
American Home Products Corporation
Patent: US5723468 A1, 1998 ;
US 5723468 A
反应条件
1: 60 percent / aq. HCl; SnCl2*2H2O / 1 h / 90 °C 2: 68 percent / aq. HCl / dimethylformamide / 12 h / 20 °C View Scheme
参考文献
Minetti, Patrizia; Tinti, Maria Ornella; Carminati, Paolo; Castorina, Massimo; Di Cesare, Maria Assunta; Di Serio, Stefano; Gallo, Grazia; Ghirardi, Orlando; Giorgi, Fabrizio; Giorgi, Luca; Piersanti, Giovanni; Bartoccini, Francesca; Tarzia, Giorgio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 6887 - 6896
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 21 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/12622 A2, 2008 ;
Location in patent: Page/Page column 55-56 ;
WO 2008/012622 A2
反应条件
1: H2 / 5percent Pd/C / ethanol
2: 36 percent / 20 h / 120 °C
View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
反应条件
1.1: 60 percent / aq. HCl; SnCl2*2H2O / 1 h / 90 °C
2.1: 68 percent / aq. HCl / dimethylformamide / 12 h / 20 °C
3.1: BuLi / hexane; tetrahydrofuran / 1 h / -78 °C
3.2: 64 percent / Br2 / hexane; tetrahydrofuran / 2 h / -78 °C
View Scheme
参考文献
Minetti, Patrizia; Tinti, Maria Ornella; Carminati, Paolo; Castorina, Massimo; Di Cesare, Maria Assunta; Di Serio, Stefano; Gallo, Grazia; Ghirardi, Orlando; Giorgi, Fabrizio; Giorgi, Luca; Piersanti, Giovanni; Bartoccini, Francesca; Tarzia, Giorgio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 6887 - 6896
反应条件
1: H2 / 5percent Pd/C / ethanol
2: 62 percent / 4 h / 110 °C
View Scheme
参考文献
Katner; Brown
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 563 - 566
