N-Boc-(R)-3-甲酸哌啶合成路线 （共 24 条）
反应条件
1: With sodium hydrogencarbonate in water 2: With hydrogenchloride in water pH=2;
参考文献
WO2005/14540 A1, ;
Page/Page column 39 ;
反应条件
hydrogenchloride; sodium hydroxide; lithium hydroxide monohydrate in tetrahydrofuran; anhydrous sodium hydrogen carbonate; water; ethyl acetate
反应条件
triethylamine in methanol T=50°C; Acylation; 4 h;
参考文献
Journal of the American Chemical Society, , vol. 122, # 17 p. 3995 - 4004
反应条件
C56H72IrNOP(1+)*C32H12BF24(1-); hydrogen; caesium carbonate in methanol T=60°C; P=4560.31 Torr; 12 h; Autoclave; Reagent/catalystConcentration; enantioselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 23 p. 6072 - 6075
Angew. Chem., , vol. 125, # 23 p. 6188 - 6191
反应条件
hydrogenchloride; LiOH; triethylamine in 1,4-dioxane; methanol; water; ethyl acetate
参考文献
US6645980 B1, ;
US 6645980 B1
反应条件
lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=0 - 6°C; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 3 p. 610 - 625
反应条件
C51H54IrNOP(1+)*C32H12BF24(1-); hydrogen; caesium carbonate in methanol T=60°C; P=4560.31 Torr; 12 h; Autoclave; enantioselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 23 p. 6072 - 6075
Angew. Chem., , vol. 125, # 23 p. 6188 - 6191
反应条件
1: water; acetone / 15 h / 20 °C / Reflux 2: triethylamine / methanol / 4 h / 0 - 50 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 30 p. 6169 - 6185
反应条件
1: potassium carbonate; water / 0.5 h / 20 °C 2: 1,2-dichloro-ethane / 0.67 h / 0 °C / |Reflux 3: methanol / 2 h / |Reflux 4: hydrogen bromide / water / 2 h / |Reflux 5: sodium hydroxide / tert-butyl alcohol / 2 h / 45 - 50 °C 6: C56H72IrNOP(1+)*C32H12BF24(1-); caesium carbonate; hydrogen / methanol / 12 h / 60 °C / 4560.31 Torr / |Autoclave View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 23 p. 6072 - 6075
Angew. Chem., , vol. 125, # 23 p. 6188 - 6191
反应条件
1: methanol / 2 h / |Reflux 2: hydrogen bromide / water / 2 h / |Reflux 3: sodium hydroxide / tert-butyl alcohol / 2 h / 45 - 50 °C 4: C56H72IrNOP(1+)*C32H12BF24(1-); caesium carbonate; hydrogen / methanol / 12 h / 60 °C / 4560.31 Torr / |Autoclave View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 23 p. 6072 - 6075
Angew. Chem., , vol. 125, # 23 p. 6188 - 6191
