(2S,3R)-3-[(苄氧羰基)氨基]-4-苯硫基-1-环氧丁烯合成路线 （共 12 条）
反应条件
potassium hydroxide in 1,4-dioxane; water T=20°C; Cyclization; 1 h;
参考文献
PFIZER INC.
Patent: WO2004/99129 A2, 2004 ;
Location in patent: Page 36-37 ;
反应条件
sodium hydrogencarbonate in 1,4-dioxane; toluene
参考文献
Japan Tobacco Inc.; Agouron Pharmaceuticals, Inc.
Patent: US5962704 A1, 1999 ;
反应条件
sodium hydroxide in water; isopropyl alcohol T=22 - 45°C; 1 - 2 h;
参考文献
EP1361216 A1, ;
Page/Page column 28 ;
反应条件
1: H2 / Pd/C / propan-2-ol / 9 h / 60 °C 2: K2CO3 / toluene; H2O / 3 h / 20 °C 3: Et3N / toluene / 1.5 h / 10 °C 4: 1.93 kg / NaOH; Bu4NBr / toluene; H2O / 2.5 h / 55 °C 5: aq. HCl / methanol / 3.5 h / Heating 6: 2-picoline / ethyl acetate / 8.5 h / 5 - 10 °C 7: 1.31 kg / Et3N / ethyl acetate / 0.5 h 8: 98 percent / KOH / dioxane; H2O / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 6 p. 1623 - 1628
反应条件
1: NaHCO3 / toluene; H2O 2: PPTS / acetone 3: Et3N / toluene / 1.5 h / 10 °C 4: 1.93 kg / NaOH; Bu4NBr / toluene; H2O / 2.5 h / 55 °C 5: aq. HCl / methanol / 3.5 h / Heating 6: 2-picoline / ethyl acetate / 8.5 h / 5 - 10 °C 7: 1.31 kg / Et3N / ethyl acetate / 0.5 h 8: 98 percent / KOH / dioxane; H2O / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 6 p. 1623 - 1628
反应条件
1: Et3N / toluene / 1.5 h / 10 °C 2: 1.93 kg / NaOH; Bu4NBr / toluene; H2O / 2.5 h / 55 °C 3: aq. HCl / methanol / 3.5 h / Heating 4: 2-picoline / ethyl acetate / 8.5 h / 5 - 10 °C 5: 1.31 kg / Et3N / ethyl acetate / 0.5 h 6: 98 percent / KOH / dioxane; H2O / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 6 p. 1623 - 1628
反应条件
1: PPTS / acetone 2: Et3N / toluene / 1.5 h / 10 °C 3: 1.93 kg / NaOH; Bu4NBr / toluene; H2O / 2.5 h / 55 °C 4: aq. HCl / methanol / 3.5 h / Heating 5: 2-picoline / ethyl acetate / 8.5 h / 5 - 10 °C 6: 1.31 kg / Et3N / ethyl acetate / 0.5 h 7: 98 percent / KOH / dioxane; H2O / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 6 p. 1623 - 1628
反应条件
1: 2-picoline / ethyl acetate / 8.5 h / 5 - 10 °C 2: 1.31 kg / Et3N / ethyl acetate / 0.5 h 3: 98 percent / KOH / dioxane; H2O / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 6 p. 1623 - 1628
反应条件
1: 1.93 kg / NaOH; Bu4NBr / toluene; H2O / 2.5 h / 55 °C 2: aq. HCl / methanol / 3.5 h / Heating 3: 2-picoline / ethyl acetate / 8.5 h / 5 - 10 °C 4: 1.31 kg / Et3N / ethyl acetate / 0.5 h 5: 98 percent / KOH / dioxane; H2O / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 6 p. 1623 - 1628
反应条件
1: aq. HCl / methanol / 3.5 h / Heating 2: 2-picoline / ethyl acetate / 8.5 h / 5 - 10 °C 3: 1.31 kg / Et3N / ethyl acetate / 0.5 h 4: 98 percent / KOH / dioxane; H2O / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 6 p. 1623 - 1628
