2-硝基-4,6-二甲基苯胺合成路线 （共 25 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=1292.9 Torr; 2 h;
参考文献
Cai, Sui Xiong; Zhou, Zhang-Lin; Huang, Jin-Cheng; Whittemore, Edward R.; Egbuwoku, Zizi O.; Lue, Yixin; Hawkinson, Jon E.; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3248 - 3255
反应条件
palladium monocarbide in ethanol
参考文献
State of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon, Eugene Oregon; Acea Pharmaceuticals, Inc.; The Regents of the University of California
Patent: US5631373 A1, 1997 ;
反应条件
palladium monocarbide in ethanol
参考文献
State of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon, Eugene Oregon; Acea Pharmaceuticals, Inc.; The Regents of the University of California
Patent: US5631373 A1, 1997 ;
反应条件
1: 5-nitro-4-amino-1,3-dimethylbenzene With hydrogen; palladium 10 on activated carbon in ethanol P=760.051 Torr; 3 h; 2: bis(trichloromethyl) carbonate in acetonitrile 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2008/130512 A1, 2008 ;
Location in patent: Page/Page column 61-62 ;
WO 2008/130512 A1
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) /BRN= 3587244/ 2: Sn, aq. HCl / acetic acid View Scheme
参考文献
Andrews,B.D. et al.
Australian Journal of Chemistry, 1972 , vol. 25, p. 639 - 646
反应条件
hydrogenchloride; tetrafluoroboric acid; sodium nitrite Erhitzen des Reaktionsprodukts auf 220grad;
参考文献
Gingras; Bayley
Canadian Journal of Chemistry, 1959 , vol. 37, p. 988,992
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) /BRN= 3587244/ 2: (i) H2SO4, (ii) aq. NaNO2 3: diethyl ether View Scheme
参考文献
Andrews,B.D. et al.
Australian Journal of Chemistry, 1972 , vol. 25, p. 639 - 646
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) /BRN= 3587244/ 2: (i) H2SO4, (ii) aq. NaNO2 3: diethyl ether 4: H2 / Pd-C / ethanol View Scheme
参考文献
Andrews,B.D. et al.
Australian Journal of Chemistry, 1972 , vol. 25, p. 639 - 646
反应条件
durch Entamidierung;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 207, p. 94
反应条件
1.1: NaNO2; conc. H2SO4 / acetic acid / 15 - 75 °C
1.2: 69 percent / aq. KI; urea
2.1: 84 percent / Cu / dimethylformamide / Heating
3.1: 87 percent / Na2S2 / ethanol / Heating
View Scheme
参考文献
Liang, Yuxue; Gao, Shuang; Wan, Huihui; Wang, Junwei; Chen, Huilin; Zheng, Zhuo; Hu, Xinquan
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1267 - 1273
