(1R,4S)-2-氧代-7-氮杂双环[2.2.1]庚烷-7-羧酸叔丁酯合成路线 （共 72 条）
反应条件
1: 76 percent / Bu3SnH, AIBN / toluene / 110 °C 2: 95 percent / O3, Me2S, Sudan III / CH2Cl2; methanol / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 27 p. 4789 - 4792
反应条件
1: 76 percent / Bu3SnH, AIBN / toluene / 80 °C 2: 80 percent / TsOH*H2O / CH2Cl2 3: 76 percent / Bu3SnH, AIBN / toluene / 110 °C 4: 95 percent / O3, Me2S, Sudan III / CH2Cl2; methanol / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 27 p. 4789 - 4792
反应条件
1: 90 percent / DMAP / CH2Cl2 2: 89 percent / DIBAL-H / CH2Cl2; tetrahydrofuran / -78 °C 3: 81 percent / TsOH*H2O 4: 73 percent / DIBAL-H / CH2Cl2 / -78 °C 5: 90 percent / tetrahydrofuran / -78 °C 6: 77 percent / DMAP / CH2Cl2 7: 76 percent / Bu3SnH, AIBN / toluene / 80 °C 8: 80 percent / TsOH*H2O / CH2Cl2 9: 76 percent / Bu3SnH, AIBN / toluene / 110 °C 10: 95 percent / O3, Me2S, Sudan III / CH2Cl2; methanol / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 27 p. 4789 - 4792
反应条件
1: 100 percent / diethyl ether 2: 90 percent / DMAP / CH2Cl2 3: 89 percent / DIBAL-H / CH2Cl2; tetrahydrofuran / -78 °C 4: 81 percent / TsOH*H2O 5: 73 percent / DIBAL-H / CH2Cl2 / -78 °C 6: 90 percent / tetrahydrofuran / -78 °C 7: 77 percent / DMAP / CH2Cl2 8: 76 percent / Bu3SnH, AIBN / toluene / 80 °C 9: 80 percent / TsOH*H2O / CH2Cl2 10: 76 percent / Bu3SnH, AIBN / toluene / 110 °C 11: 95 percent / O3, Me2S, Sudan III / CH2Cl2; methanol / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 27 p. 4789 - 4792
反应条件
1: 93 percent / carbon tetrabromide; triphenylphosphine / CH2Cl2 2: 80 percent / potassium tert-butoxide / dimethylsulfoxide 3: 95 percent / ozone / methanol View Scheme
参考文献
Heterocycles, , vol. 57, # 5 p. 781 - 785
反应条件
1: 80 percent / potassium tert-butoxide / dimethylsulfoxide 2: 95 percent / ozone / methanol View Scheme
参考文献
Heterocycles, , vol. 57, # 5 p. 781 - 785
反应条件
1: 57 percent / tetrabutylammonium fluoride / tetrahydrofuran 2: 93 percent / carbon tetrabromide; triphenylphosphine / CH2Cl2 3: 80 percent / potassium tert-butoxide / dimethylsulfoxide 4: 95 percent / ozone / methanol View Scheme
参考文献
Heterocycles, , vol. 57, # 5 p. 781 - 785
反应条件
1: 71 percent / potassium tert-butoxide / dimethylformamide; benzene 2: 57 percent / tetrabutylammonium fluoride / tetrahydrofuran 3: 93 percent / carbon tetrabromide; triphenylphosphine / CH2Cl2 4: 80 percent / potassium tert-butoxide / dimethylsulfoxide 5: 95 percent / ozone / methanol View Scheme
参考文献
Heterocycles, , vol. 57, # 5 p. 781 - 785
反应条件
1: Jones reagent / acetone / 1.5 h / 20 °C 2: 156 mg / toluene / 24 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 54, # 3 p. 399 - 402
反应条件
1.1: O3 / CH2Cl2 / -78 °C 1.2: 93 percent / Me2S / CH2Cl2 / 24 h / 20 °C 2.1: Jones reagent / acetone / 1.5 h / 20 °C 3.1: 156 mg / toluene / 24 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 54, # 3 p. 399 - 402
