5-(4-(4-(5-氰基-1H-吲哚-3-基)丁基)哌嗪-1-基)苯并呋喃-2-羧酸合成路线 （共 8 条）
反应条件
1: 93 percent / H2 / Raney Ni / methanol / 27 h / 28 °C 2: 27 percent / K2CO3 / butan-1-ol / 48 h / Heating 3: K2CO3; Et3N / acetonitrile / 12 h / Heating 4: KOH / methanol / 3 h / Heating View Scheme
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
反应条件
potassium hydroxide in methanol 3 h; Heating;
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
反应条件
1: 73 percent / isobutyl-AlCl2 / CH2Cl2 / 15 - 30 °C 2: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 3: K2CO3; Et3N / acetonitrile / 12 h / Heating 4: KOH / methanol / 3 h / Heating View Scheme
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
反应条件
1: 27 percent / K2CO3 / butan-1-ol / 48 h / Heating 2: K2CO3; Et3N / acetonitrile / 12 h / Heating 3: KOH / methanol / 3 h / Heating View Scheme
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
反应条件
1: K2CO3; Et3N / acetonitrile / 12 h / Heating 2: KOH / methanol / 3 h / Heating View Scheme
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
反应条件
1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; Et3N / acetonitrile / 12 h / Heating 3: KOH / methanol / 3 h / Heating View Scheme
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
反应条件
N,N-diethyl-N-isopropylamine; 2-chloro-1-methyl-pyridinium iodide; ammonia in 1-methyl-pyrrolidin-2-one
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
参考文献
Merck Patent Gesellschaft mit beschrankter Haftung
Patent: US5532241 A1, 1996 ;
US 5532241 A
