6-碘喹唑啉-2,4(1h,3h)-二酮合成路线 （共 10 条）
反应条件
1: With acetic acid in water T=40°C; 8 h; 2: With sodium hydroxide in water T=40°C; 3: With hydrogenchloride in water pH=4;
参考文献
Gruenenthal GmbH
Patent: US2009/69320 A1, 2009 ;
Location in patent: Page/Page column 66 ;
反应条件
1: 92 percent / dioxane / 60 °C 2: 97 percent / 4-(dimethylamino)pyridine / methanol / 3 h / 60 °C 3: 70 percent / H2O; acetic acid / Heating 4: 60.5 g / aq. NaOH / methanol / 1 h / Heating View Scheme
参考文献
Ono Pharmaceutical Co., Ltd.
Patent: US5436233 A1, 1995 ;
反应条件
1: T=160°C; 6 h; 2: With sodium hydroxide in water Heating;
参考文献
Smits, Rogier A.; Adami, Maristella; Istyastono, Enade P.; Zuiderveld, Obbe P.; Van Dam, Cindy M. E.; De Kanter, Frans J. J.; Jongejan, Aldo; Coruzzi, Gabriella; Leurs, Rob; De Esch, Iwan J. P.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 6 p. 2390 - 2400
反应条件
zinc(II) chloride T=200°C; 5 h; sealed tube;
参考文献
Jiarong, Li; Xian, Chen; Daxin, Shi; Shuling, Ma; Qing, Li; Qi, Zhang; Jianhong, Tang
Organic Letters, 2009 , vol. 11, # 6 p. 1193 - 1196
反应条件
sodium hydroxide in methanol 1 h; Heating;
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
1: 97 percent / 4-(dimethylamino)pyridine / methanol / 3 h / 60 °C 2: 70 percent / H2O; acetic acid / Heating 3: 60.5 g / aq. NaOH / methanol / 1 h / Heating View Scheme
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
1: 70 percent / H2O; acetic acid / Heating 2: 60.5 g / aq. NaOH / methanol / 1 h / Heating View Scheme
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
N,N-dimethyl-aniline; trichlorophosphate T=150°C; 2 h;
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
1: 89 percent / POCl3, N,N-dimethylaniline / 2 h / 150 °C 2: 96 percent / NaBH4 / CHCl3; ethanol / 1.) 0 deg C, 2.) room temperature, 1 h 3: 84 percent / potassium carbonate / butan-2-one / Heating View Scheme
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
1: 75 percent / phosphorus oxychloride; N,N-diethylaniline / 4 h / Heating
2: 91 percent / methanol / 18 h / Heating
View Scheme
参考文献
Lee, Alex H. F.; Kool, Eric T.
Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 132 - 140
