(R)-1-苯基-1,2-乙二醇合成路线 （共 159 条）
反应条件
sodium tetrahydroborate; chloro-trimethyl-silane; polymer-supported chiral sulfonamide in tetrahydrofuran Heating; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 5 p. 807 - 810
反应条件
sodium tetrahydroborate; chloro-trimethyl-silane; polymer-supported chiral sulfonamide in tetrahydrofuran Heating; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 5 p. 807 - 810
反应条件
1: With ozone 2: With sodium tetrahydroborate
参考文献
Organic Letters, , vol. 7, # 9 p. 1729 - 1732
反应条件
1: SmI2 / tetrahydrofuran; methanol / 0.5 h / Ambient temperature 2: 80 percent / CSA / CHCl3 / 2 h / Heating 3: 94 percent / TBAF / tetrahydrofuran / 12 h / Ambient temperature 4: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 45 min, 2.) -78 deg C to r.t., 12 h 5: SmI2 / tetrahydrofuran; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 12 p. 1639 - 1645
反应条件
1: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 45 min, 2.) -78 deg C to r.t., 12 h 2: SmI2 / tetrahydrofuran; methanol / 0.5 h / Ambient temperature 3: 80 percent / CSA / CHCl3 / 2 h / Heating 4: 94 percent / TBAF / tetrahydrofuran / 12 h / Ambient temperature 5: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 45 min, 2.) -78 deg C to r.t., 12 h 6: SmI2 / tetrahydrofuran; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 12 p. 1639 - 1645
反应条件
1: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 45 min, 2.) -78 deg C to r.t., 12 h 2: SmI2 / tetrahydrofuran; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 12 p. 1639 - 1645
反应条件
1: 93 percent / TBAF / tetrahydrofuran / 12 h / Ambient temperature 2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 45 min, 2.) -78 deg C to r.t., 12 h 3: SmI2 / tetrahydrofuran; methanol / 0.5 h / Ambient temperature 4: 80 percent / CSA / CHCl3 / 2 h / Heating 5: 94 percent / TBAF / tetrahydrofuran / 12 h / Ambient temperature 6: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 45 min, 2.) -78 deg C to r.t., 12 h 7: SmI2 / tetrahydrofuran; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 12 p. 1639 - 1645
反应条件
1: 94 percent / TBAF / tetrahydrofuran / 12 h / Ambient temperature 2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 45 min, 2.) -78 deg C to r.t., 12 h 3: SmI2 / tetrahydrofuran; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 12 p. 1639 - 1645
反应条件
1: silver(l) oxide / dichloromethane / 0 - 20 °C 2: DAHP; [14C]-Sucrose / ethanol; water / 18 h / 28 - 30 °C / Microbiological reaction View Scheme
参考文献
Synthesis, , # 2 art. no. P14610SS, p. 316 - 324
反应条件
1.1: Pt(dibenzylideneacetone)3; (3R,5R)-5-(tert-butyl)-2,2-diisobutyl-3-phenyl-1,3-oxaphospholane; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane / toluene / 12 h / 60 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: ozone / methanol; dichloromethane / -78 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 34 p. 7906 - 7909
