(R)-1-苯基-1,2-乙二醇合成路线 （共 159 条）
反应条件
Candida parapsilosis (R)-specific alcohol dehydrogenase; nicotinamide adenine dinucleotide T=30°C; pH=9; aq. buffer; Kinetics; Reagent/catalystConcentrationpH-valueTemperature;
参考文献
Hamnevik, Emil; Blikstad, Cecilia; Norrehed, Sara; Widersten, Mikael
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 99, p. 68 - 78
反应条件
1: Rhodococcus ruber DSM 44541 alcoholdehydrogenase A; nicotinamide adenine dinucleotide / aq. phosphate buffer; acetonitrile / 30 °C / pH 8 / |Enzymatic reaction 2: Rhodococcus ruber DSM 44541 alcoholdehydrogenase A; nicotinamide adenine dinucleotide / aq. phosphate buffer; acetonitrile / 30 °C / pH 8 / |Enzymatic reaction View Scheme
参考文献
Hamnevik, Emil; Blikstad, Cecilia; Norrehed, Sara; Widersten, Mikael
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 99, p. 68 - 78
反应条件
1: pyridine / 4 h / -10 °C 2: LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Mangold, James B.; Abdel-Monem, Mahmoud M.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 66 - 71
反应条件
pyridine anschliessend mit wss.-methanol.Kalilauge;
参考文献
Eliel; Delmonte
Journal of Organic Chemistry, 1956 , vol. 21, p. 596
反应条件
orthoacetic acid trimethyl ester; chloro-trimethyl-silane; potassium carbonate 1.) CH2Cl2; 2.) MeOH; Yield given. Multistep reaction;
参考文献
Dvorak, Curt A.; Rawal, Viresh H.
Tetrahedron Letters, 1998 , vol. 39, # 19 p. 2925 - 2928
反应条件
1: 87 percent / DMAP; triethylamine / CH2Cl2 / 2 h / 20 °C 2: 97 percent / DIAD; Ph3P / tetrahydrofuran / -20 - 20 °C 3: 85 percent / LiBEt3H / tetrahydrofuran; diethyl ether / 1.5 h / -50 °C 4: 99 percent / TBAF*3H2O / acetonitrile View Scheme
参考文献
Atobe, Masakazu; Yamazaki, Naoki; Kibayashi, Chihiro
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5595 - 5607
反应条件
1: 76 percent / pyridine / 4 h / -10 °C 2: 93 percent / NaN3 / dimethylformamide / 2 h / 90 - 95 °C 3: 90 percent / LiAlH4 / diethyl ether / 3 h / Heating View Scheme
参考文献
Uccello-Barretta, Gloria; Cuzzola, Angela; Balzano, Federica; Menicagli, Rita; Iuliano, Anna; Salvadori, Piero
Journal of Organic Chemistry, 1997 , vol. 62, # 4 p. 827 - 835
反应条件
1: 100 percent / SOCl2 / CCl4 / Heating 2: 81 percent / LiN3 / dimethylformamide / 120 °C 3: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Lohray, Braj B.; Ahuja, Jaimala R.
Journal of the Chemical Society, Chemical Communications, 1991 , # 2 p. 95 - 97
反应条件
1: 76 percent / pyridine / 4 h / -10 °C
2: 93 percent / NaN3 / dimethylformamide / 2 h / 90 - 95 °C
View Scheme
参考文献
Uccello-Barretta, Gloria; Cuzzola, Angela; Balzano, Federica; Menicagli, Rita; Iuliano, Anna; Salvadori, Piero
Journal of Organic Chemistry, 1997 , vol. 62, # 4 p. 827 - 835
