(R)-1-苯基-1,2-乙二醇合成路线 （共 159 条）
反应条件
1.1: conc. HCl / methanol / 0.5 h / 20 °C 1.2: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating 2.1: 99 percent / TsOH / toluene / 0.5 h / Heating 3.1: 60 percent / toluene; diethyl ether / 0.42 h / -20 °C 4.1: Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 17 p. 5595 - 5607
反应条件
1.1: 99 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 9 h / 20 °C 2.1: conc. HCl / methanol / 0.5 h / 20 °C 2.2: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating 3.1: 99 percent / TsOH / toluene / 0.5 h / Heating 4.1: 60 percent / toluene; diethyl ether / 0.42 h / -20 °C 5.1: Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 17 p. 5595 - 5607
反应条件
1.1: 99 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C 2.1: 99 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 9 h / 20 °C 3.1: conc. HCl / methanol / 0.5 h / 20 °C 3.2: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating 4.1: 99 percent / TsOH / toluene / 0.5 h / Heating 5.1: 60 percent / toluene; diethyl ether / 0.42 h / -20 °C 6.1: Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 17 p. 5595 - 5607
反应条件
1: 99 percent / TsOH / toluene / 0.5 h / Heating 2: 60 percent / toluene; diethyl ether / 0.42 h / -20 °C 3: Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 17 p. 5595 - 5607
反应条件
1.1: n-BuLi / hexane; toluene / 0.17 h / -78 °C 1.2: (-)-sparteine / hexane; toluene / 1 h / -78 °C 1.3: 74 percent / hexane; toluene / 0.5 h / -78 °C 2.1: pyridine; 4-dimethylaminopyridine / 3 h / 20 °C 3.1: aq. HgCl2 / acetonitrile / 6 h / 20 °C 4.1: LiAlH4 / tetrahydrofuran / 3 h / 0 - 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 15 p. 2168 - 2169
反应条件
sodium tetrahydroborate in methanol 0.166667 h;
参考文献
Tetrahedron, , vol. 64, # 39 p. 9320 - 9344
反应条件
Colletotrichum crassipes; PDB medium in ethanol T=25°C; 240 h; Microbiological reaction; optical yield given as percent ee;
参考文献
Pinedo-Rivilla, Cristina; Cafeu, Mariana Carrara; Casatejada, Josefina Aleu; Araujo, Angela Regina; Collado, Isidro G.
Tetrahedron Asymmetry, 2009 , vol. 20, # 23 p. 2666 - 2672
反应条件
benzaldehyde lyase; formaldehyde dehydrogenase from Pseudomonas putida; glycerol dehydrogenase from Cellulomonas sp.; thiamine diphosphate-dependent lyase; nicotinamide adenine dinucleotide; magnesium sulfate; Reduced nicotinamide-adenine dinucleotide in 2-methyl tetrahydrofuran pH=8; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Shanmuganathan, Saravanakumar; Natalia, Dessy; Greiner, Lasse; Dominguez De Maria, Pablo
Green Chemistry, 2012 , vol. 14, # 1 p. 94 - 97
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 3 h; Title compound not separated from byproducts;
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 15 p. 2168 - 2169
反应条件
1: toluene; diethyl ether / 0.42 h / 0 °C 2: Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 17 p. 5595 - 5607
