1: 75 percent / NaOMe / methanol / 3 h / 0 °C 2: CF3SO3H / cyclohexane; CH2Cl2 / 0.5 h / Ambient temperature 3: TFA / CH2Cl2 / 22 h / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1708400', constants.ctx, '0')">2,2'-azo-bisisobutyronitrile</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587329', constants.ctx, '0')">tri-n-butyl-tin hydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '969212', constants.ctx, '0')">benzene</a> <br />6&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;

Stage #1: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '10512883', constants.ctx, '0')">Grubb's 2nd generation catalyst</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11405916', constants.ctx, '0')">copper(l) iodide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=40&deg;C;&nbsp;<br />Stage #2: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11323294', constants.ctx, '0')">platinum(IV) oxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506104', constants.ctx, '0')">ethyl acetate</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: PS amano lipase / pentane / 18 h / 30 &deg;C / |Molecular sieve; |Enzymatic reaction<br />2: Grubb's 2nd generation catalyst; copper(l) iodide / diethyl ether / 40 &deg;C<br /> <br /> &nbsp;