2’-O-(2-甲氧基乙基)-5-甲基尿苷合成路线 （共 48 条）
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; 2: With water 0.5 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/225015 A1, 2003 ;
Location in patent: Page 18-19 ;
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; 2: With water 0.5 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232770 A1, 2003 ;
Location in patent: Page 18 ;
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; Heating / reflux; 2: With water 0.5 h; Heating / reflux;
参考文献
US2003/224511 A1, ;
Page 18-19 ;
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; 2: With water 0.5 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/23384 A1, 2004 ;
Location in patent: Page/Page column 19 ;
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; 2: With water 0.5 h; Heating / reflux;
参考文献
US2004/5705 A1, ;
Page/Page column 19 ;
反应条件
1: With 2-methoxy-ethanol; sodium hydrogencarbonate T=130°C; 21 h; 2: With water 0.5 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/23382 A1, 2004 ;
Location in patent: Page/Page column 19 ;
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; Heating / reflux; 2: With water 0.5 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232436 A1, 2003 ;
Location in patent: Page 18 ;
反应条件
1: With sodium hydrogencarbonate T=130°C; 21 h; 2: With water 0.5 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/29273 A1, 2004 ;
Location in patent: Page/Page column 18-19 ;
US 20040029273 A1
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; 2: in water T=100°C; 0.5 h;
参考文献
Isis Pharmaceuticals, Inc.
Patent: US2004/14699 A1, 2004 ;
Location in patent: Page/Page column 18 ;
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in methanol T=45°C; P=2250.2 Torr;
参考文献
Martin
Helvetica Chimica Acta, 1995 , vol. 78, # 2 p. 486 - 504
