2’-O-(2-甲氧基乙基)-5-甲基尿苷合成路线 （共 48 条）
反应条件
1: With tris(1,4-dioxapentane)borate; sodium hydrogencarbonate T=130°C; P=760.051 Torr; 21 h; Argon atmosphere; 2: With water 0.5 h; Heating / reflux;
参考文献
ISIS PHARMACEUTICALS, INC.
Patent: WO2003/99840 A1, 2003 ;
Location in patent: Page 223-224 ;
反应条件
tris(2-methoxyethyl) borate; sodium hydrogencarbonate T=130°C; 21 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/225256 A1, 2003 ;
Location in patent: Page 18 ;
反应条件
in 2-methoxy-ethanol T=155 - 160°C; 48 h;
参考文献
Isis Pharmaceuticals Inc.; Abbott Laboratories
Patent: US2004/77567 A1, 2004 ;
Location in patent: Page/Page column 16 ;
反应条件
in 2-methoxy-ethanol; water T=155 - 160°C; 48 h;
参考文献
Bhanot, Sanjay; Monia, Brett P.; Geary, Richard S.; Kjems, Lise Lund
Patent: US2006/89325 A1, 2006 ;
Location in patent: Page/Page column 14-15 ;
反应条件
tris(1,4-dioxapentane)borate; sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232771 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
Candida antarctica lipase B; phosphate buffer in 1,4-dioxane T=40°C; pH=7; 96 h;
参考文献
Garcia, Javier; Fernandez, Susana; Ferrero, Miguel; Sanghvi, Yogesh S.; Gotor, Vicente
Journal of Organic Chemistry, 2002 , vol. 67, # 13 p. 4513 - 4519
反应条件
in dichloromethane; 2-methoxy-ethanol; acetone; acetonitrile
反应条件
phosphate buffer; Pseudomonas cepacia lipase in 1,4-dioxane T=40°C; pH=7; 168 h;
参考文献
Garcia, Javier; Fernandez, Susana; Ferrero, Miguel; Sanghvi, Yogesh S.; Gotor, Vicente
Journal of Organic Chemistry, 2002 , vol. 67, # 13 p. 4513 - 4519
反应条件
sodium methylate in methanol T=20°C; 1 h;
参考文献
Martin, Pierre
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 204 - 209
反应条件
tris(1,4-dioxapentane)borate; 2-methoxy-ethanol T=155 - 160°C; 48 h;
参考文献
WO2004/9541 A2, ;
Page 52 ;
