2’-O-(2-甲氧基乙基)-5-甲基尿苷合成路线 （共 48 条）
反应条件
1: With dichloro-acetic acid; pyrrole in dichloromethane 2: With triethylamine in methanol; dichloromethane
参考文献
Tetrahedron Letters, , vol. 53, # 35 p. 4669 - 4672
反应条件
1: With dichloro-acetic acid; pyrrole in dichloromethane 2: With triethylamine in methanol; dichloromethane
参考文献
Tetrahedron Letters, , vol. 53, # 35 p. 4669 - 4672
反应条件
1: With dichloro-acetic acid; pyrrole in dichloromethane 2: With triethylamine in methanol; dichloromethane
参考文献
Tetrahedron Letters, , vol. 53, # 35 p. 4669 - 4672
反应条件
1.1: pyridine
2.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 5 °C
2.2: phosphorus oxychloride; 1,2,4-triazole / -20 - 5 °C
2.3: aq. NH3 / dioxane / 25 °C
3.1: dimethylformamide / 24 h / 25 °C
View Scheme
参考文献
Ross, Bruce S.; Song, Quanlai; Han, Mingming
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 815 - 818
反应条件
lutidine in acetonitrile
T=-10 - -2°C; 1 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/225015 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
lutidine in acetonitrile
T=-10 - 3°C; 1.5 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/236206 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
1: 4,4'-dimethoxytriphenylmethyl chloride; 2'-O-(2-methoxyethyl)-5-methyluridine With 2,6-dimethylpyridine in acetonitrile
T=-10 - -3°C; 1.41667 h;
2: methanol in acetonitrile
0.166667 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/23384 A1, 2004 ;
Location in patent: Page/Page column 19-20 ;
反应条件
2,6-dimethylpyridine in acetonitrile
T=-15 - 3°C; 1.41667 - 1.5 h;
参考文献
Song, Quanlai; Ross, Bruce S.
Patent: US2004/158055 A1, 2004 ;
Location in patent: Page 25-27 ;
