1.1: n-BuLi / tetrahydrofuran / 0.08 h / -78 °C 1.2: tetrahydrofuran / 1 h / -78 - 20 °C 1.3: aq. HCl / tetrahydrofuran; methanol; propan-2-ol / 12 h / Heating 2.1: t-BuOK / 1,2-dimethoxy-ethane / 0.5 h / 20 °C 2.2: 81 percent / 1,2-dimethoxy-ethane / 12 h / Heating 3.1: 64 percent / (PPh3)2Pd(OAc)2; KOAc / acetonitrile / 12 h / 100 °C View Scheme

1: 5-iodo-4H-1,3-dioxa-8-azanaphthalene With n-butyllithium in tetrahydrofuran T=-78°C; 0.0833333 h; 2: 2-oxo-butyric acid 2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester in tetrahydrofuran T=-78 - 20°C; 1 h; 3: With hydrogenchloride in tetrahydrofuran; methanol; isopropyl alcohol 12 h; Heating; Further stages. Title compound not separated from byproducts.;