5-甲基吲哚-2-甲基酸酯合成路线 （共 13 条）
反应条件
1: p-toluidine With hydrogenchloride; sodium nitrite in water T=-5°C; 0.25 h; 2: 2-methyl-3-oxobutanoic acid ethyl ester With potassium hydroxide; sodium acetate in ethanol; water T=0°C; 18 h; 3: With toluene-4-sulfonic acid in toluene T=110°C; 5 h;
参考文献
Bignon, Eric; Bras, Jean Pierre; De Cointet, Paul; Despeyroux, Pierre; Frehel, Daniel; Gully, Danielle
Patent: US2004/43995 A1, 2004 ;
Location in patent: Page 13 ;
US 20040043995 A1
反应条件
amberlyst-15 in toluene T=110°C; 5 h;
参考文献
Murakami, Yasuoki; Yokoyama, Yuusaku; Miura, Tomoko; Hirasawa, Hiroko; Kamimura, Yuuko; Izaki, Miyako
Heterocycles, 1984 , vol. 22, # 5 p. 1211 - 1216
反应条件
copper(l) iodide; caesium carbonate in dimethyl sulfoxide T=50°C; 4 h; Inert atmosphere;
参考文献
Cai, Qian; Li, Zhengqiu; Wei, Jiajia; Ha, Chengyong; Pei, Duanqing; Ding, Ke
Chemical Communications, 2009 , # 48 p. 7581 - 7583
反应条件
toluene-4-sulfonic acid in benzene T=50°C; 1.8 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 47, # 6 p. 791 - 797
反应条件
tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate in acetonitrile T=80°C; Heck-Jeffery amination; 96 h; Inert atmosphere;
参考文献
McNulty, James; Keskar, Kunal
European Journal of Organic Chemistry, 2011 , # 34 p. 6902 - 6908
反应条件
hydrogenchloride T=65 - 70°C;
参考文献
Journal of Biological Chemistry, , vol. 62, p. 507
反应条件
1: benzene / 2 h / Reflux 2: diethylphosphoric acid ethyl ester / 3 h / Reflux View Scheme
参考文献
Bulletin of the Korean Chemical Society, , vol. 32, # 12 p. 4309 - 4315
反应条件
1: potassium dichromate / dichloromethane 2: benzene / 2 h / Reflux 3: diethylphosphoric acid ethyl ester / 3 h / Reflux View Scheme
参考文献
Bulletin of the Korean Chemical Society, , vol. 32, # 12 p. 4309 - 4315
反应条件
1: tin (II)-chloride; hydrochloric acid 3: hydrogen chloride / 65 - 70 °C View Scheme
参考文献
Journal of Biological Chemistry, , vol. 62, p. 507
反应条件
2: hydrogen chloride / 65 - 70 °C View Scheme
参考文献
Journal of Biological Chemistry, , vol. 62, p. 507
