5,6-二甲氧基吲哚-2-甲酸乙酯合成路线 （共 16 条）
反应条件
anschliessend Erhitzen mit alkoh. Salzsaeure;
参考文献
Journal of the Chemical Society, , p. 361
反应条件
1: With sodium hydroxide in methanol; water 1 h; Heating; 2: With hydrogenchloride in methanol; water T=20°C; 14 h;
参考文献
Choi, Taeyoung; Ma, Eunsook
Archives of Pharmacal Research, 2011 , vol. 34, # 3 p. 357 - 367
反应条件
1: water; sodium hydroxide / ethanol / 20 °C 2: boron tribromide / dichloromethane / -78 - 20 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 7 p. 550 - 554
反应条件
1: sodium hydride / tetrahydrofuran / 20 °C 2: lithium hydroxide hydrate / ethanol / 50 °C 3: boron tribromide / dichloromethane / -15 - 20 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 7 p. 550 - 554
反应条件
boron tribromide in dichloromethane T=-78 - 20°C; deprotection;
参考文献
Hangauer, David G.
Patent: US2008/4241 A1, 2008 ;
Location in patent: Page/Page column 136-138 ;
US 20080004241 A1
反应条件
1: 76 percent / CH3COOH / methanol / 4 h / Heating
2: 75 percent / H2, HClO4 / 10percent Pd-C / ethanol / 3 h / 50 °C / 3620.04 Torr
View Scheme
参考文献
Wadia, M. S.; Mali, R. S.; Tilve, S. G.; Yadav, V. J.
Synthesis, 1987 , # 4 p. 401 - 404
