2,2-二甲基-4-戊烯酸合成路线 （共 36 条）
反应条件
(i) LDA, (ii) /BRN= 635704/; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 89, # 10 p. 2500 - 2501
反应条件
2,2'-azo-bisisobutyronitrile; trifluoroacetic acid 1.) benzene, 80 deg C, 14 h; 2.) CHCl3; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 38, # 52 p. 8929 - 8932
反应条件
sodium hydride 1) diglyme, 1 h; 2) diglyme, 140 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Canadian Journal of Chemistry, , vol. 59, p. 3273 - 3279
反应条件
hydrogenchloride; methanol; potassium hydroxide; water; propionic acid 1) 140-150 deg C, 2a) 110 deg C, 2b) reflux, 2h; Yield given. Multistep reaction;
参考文献
Liebigs Annalen der Chemie, , # 1 p. 15 - 30
反应条件
1: 52 percent / AlCl3 / nitromethane; CH2Cl2 / 2 h / Heating 2: 66 percent / lithium tri-t-butoxyaluminium hydride / tetrahydrofuran / 2 h / -78 °C View Scheme
参考文献
Kopecky, Karl R.; Levine, Cyril
Canadian Journal of Chemistry, 1981 , vol. 59, p. 3273 - 3279
反应条件
1: lithium aluminium hydride 2: bromine, triphenylphosphine / dimethylformamide / 3 h / 110 °C 3: 1.) magnesium / in THF View Scheme
参考文献
Hill, Alexander E.; Link, Daniel C.; Donndelinger Peter
Journal of Organic Chemistry, 1981 , vol. 46, # 6 p. 1177 - 1182
反应条件
(SPY-5-31)-dichloro-(κ2(C,O)-(2-isopropyloxybenzylidene))(1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene)ruthenium; [(t-Bu3P)PdBr]2 in toluene T=100°C; P=750.075 Torr; 12 h; Autoclave;
参考文献
Chemistry - A European Journal, , vol. 19, # 30 p. 9807 - 9810
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
XenoPort, Inc.
Patent: US2009/99253 A1, 2009 ;
Location in patent: Page/Page column 46 ;
反应条件
thallium(III) nitrate in water; acetic acid 3 h; Ambient temperature;
参考文献
Ferraz; Ribeiro
Synthetic Communications, 1992 , vol. 22, # 3 p. 399 - 404
反应条件
aluminium trichloride in nitromethane; dichloromethane
2 h; Heating;
参考文献
Kopecky, Karl R.; Levine, Cyril
Canadian Journal of Chemistry, 1981 , vol. 59, p. 3273 - 3279
