2,2-二甲基-4-戊烯酸合成路线 （共 36 条）
反应条件
1: oxalyl chloride / CH2Cl2 / 3 h / 0 °C
2: SnCl4 / CH2Cl2 / 10 h / Ambient temperature
View Scheme
参考文献
Cohen; McNamara; Kuzemko; Ramig; Landi Jr.; Dong
Tetrahedron, 1993 , vol. 49, # 36 p. 7931 - 7942
反应条件
1: 91 percent / SOCl2 / CH2Cl2 / 14 h / 20 °C
2: 87 percent / CH2Cl2
View Scheme
参考文献
Schulte-Wuelwer, Iris Anne; Helaja, Juho; Goettlich, Richard
Synthesis, 2003 , # 12 p. 1886 - 1890
反应条件
1.1: 91 percent / SOCl2 / CH2Cl2 / 14 h / 20 °C
2.1: 87 percent / CH2Cl2
3.1: BuLi / diethyl ether / 0.5 h / 0 °C
3.2: 52 percent / NCS / diethyl ether / 2 h / 0 °C
View Scheme
参考文献
Schulte-Wuelwer, Iris Anne; Helaja, Juho; Goettlich, Richard
Synthesis, 2003 , # 12 p. 1886 - 1890
反应条件
1: 91 percent / SOCl2 / CH2Cl2 / 14 h / 20 °C
2: 82 percent / CH2Cl2
View Scheme
参考文献
Schulte-Wuelwer, Iris Anne; Helaja, Juho; Goettlich, Richard
Synthesis, 2003 , # 12 p. 1886 - 1890
反应条件
1: 91 percent / SOCl2 / CH2Cl2 / 14 h / 20 °C
2: 90 percent / CH2Cl2
View Scheme
参考文献
Schulte-Wuelwer, Iris Anne; Helaja, Juho; Goettlich, Richard
Synthesis, 2003 , # 12 p. 1886 - 1890
反应条件
1: 91 percent / SOCl2 / CH2Cl2 / 14 h / 20 °C
2: 79 percent / CH2Cl2
View Scheme
参考文献
Schulte-Wuelwer, Iris Anne; Helaja, Juho; Goettlich, Richard
Synthesis, 2003 , # 12 p. 1886 - 1890
反应条件
1.1: 91 percent / SOCl2 / CH2Cl2 / 14 h / 20 °C
2.1: 90 percent / CH2Cl2
3.1: BuLi / diethyl ether / 0.5 h / 0 °C
3.2: 47 percent / NCS / diethyl ether / 2 h / 0 °C
View Scheme
参考文献
Schulte-Wuelwer, Iris Anne; Helaja, Juho; Goettlich, Richard
Synthesis, 2003 , # 12 p. 1886 - 1890
反应条件
1.1: 91 percent / SOCl2 / CH2Cl2 / 14 h / 20 °C
2.1: 79 percent / CH2Cl2
3.1: BuLi / diethyl ether / 0.5 h / 0 °C
3.2: 61 percent / NCS / diethyl ether / 2 h / 0 °C
View Scheme
参考文献
Schulte-Wuelwer, Iris Anne; Helaja, Juho; Goettlich, Richard
Synthesis, 2003 , # 12 p. 1886 - 1890
反应条件
2: lithium aluminium hydride
View Scheme
参考文献
McCrindle, Robert; Alyea, Elmer C.; Ferguson, George; Dias, Shelton A.; McAlees, Alan J.; Parvez, Masood
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1980 , # 1 p. 137 - 144
反应条件
methanol in hexane
T=0°C;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/91674 A1, 2006 ;
Location in patent: Page/Page column 99 ;
WO 2006/091674 A1
