2,2-二甲基-4-戊烯酸合成路线 （共 36 条）
反应条件
sulfuric acid in methanol; toluene
参考文献
Wang, Lin; Arthur, Samuel David; McCord, Elizabeth Forrester; Wang, Yueli; Morken, Peter Arnold; Johnson, Lynda Kaye
Patent: US2003/212225 A1, 2003 ;
反应条件
in hexane; dichloromethane
0.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/67615 A2, 2007 ;
Location in patent: Page/Page column 98 ;
WO 2007/067615 A2
反应条件
meta-chloroperoxybenzoic acid; hydrogen bromide in Petroleum ether
参考文献
Sircar; Hoefle; Maxwell
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 1020 - 1027
反应条件
oxygen; bis-triphenylphosphine-palladium(II) chloride; copper diacetate in N,N-dimethyl-formamide
T=90°C; 24 h;
参考文献
Rudler, Henri; Harris, Paul; Parlier, Andree; Cantagrel, Frederic; Denise, Bernard; Bellassoued, Moncef; Vaissermann, Jacqueline
Journal of Organometallic Chemistry, 2001 , vol. 624, # 1-2 p. 186 - 202
反应条件
oxygen; tetra-(n-butyl)ammonium iodide; sodium nitrite in dichloromethane; acetic acid
T=20°C; 15 h;
参考文献
Liu, Hongjun; Pan, Yuanhang; Tan, Choon-Hong
Tetrahedron Letters, 2008 , vol. 49, # 28 p. 4424 - 4426
反应条件
1: (i) SOCl2, (ii) CS2, AlCl3
2: (i) (irradiation), pentane, (ii) MeOH
View Scheme
参考文献
Agosta,W.C.; Smith,A.B.
Journal of the American Chemical Society, 1971 , vol. 93, p. 5513 - 5520
