2,3,3-三甲基-3H-吲哚合成路线 （共 91 条）
参考文献
Song, Fengling; Wang, Li; Qiao, Xiaoqiang; Wang, Bingshuai; Sun, Shiguo; Fan, Jiangli; Zhang, Lihua; Peng, Xiaojun
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 19 p. 4249 - 4251
反应条件
in xylene
T=140°C; 2.5 h;
参考文献
Degutis, Yu. A.; Schachkus, A. A.; Urbonavichyus, A. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 7 p. 774 - 777
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , # 7 p. 933 - 935
反应条件
in acetonitrile
2 h; Reflux;
参考文献
Shin, Joung-Il; Park, Soo-Youl; Shin, Seung-Rim; Jun, Kun; Youn, Hye-Soo; An, Kyoung-Lyong; Son, Young-A
Revue Roumaine de Chimie, 2010 , vol. 55, # 10 p. 621 - 625
反应条件
1: acetonitrile / 24 h / |Reflux
2: sodium iodide / acetone / 24 h / |Reflux
View Scheme
参考文献
Tyler, Andrew R.; Okoh, Adeyi Okoh; Lawrence, Clare L.; Jones, Vicky C.; Moffatt, Colin; Smith, Robert B.
European Journal of Medicinal Chemistry, 2013 , vol. 64, p. 222 - 227
反应条件
1: 2.) Aq. NaOH / 1.) MeCN, reflux, 2.) RT
2: ethanol / Heating
View Scheme
参考文献
Lazarenko, I. B.; Przhiyalgovskaya, N. M.; Gal'bershtam, M. A.; Bobyleva, G. K.; Suvorov, N. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 10 p. 1054 - 1057
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 10 p. 1363 - 1366
反应条件
1: Na(CN)BH3, AcOH / Ambient temperature
2: aq. 70percent HNO3, H2SO4 / 0.08 h / 0 °C
3: H2 / 10percent Pd/C / ethyl acetate; ethanol / 5 h / 760 Torr
4: ZnCl2 / ethanol / 16 h / Heating
5: Na(CN)BH3, AcOH / Ambient temperature
View Scheme
参考文献
Edwards, James P.; West, Sarah J.; Pooley, Charlotte L. F.; Marschke, Keith B.; Farmer, Luc J.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 745 - 750
反应条件
1: 63 percent / acetic acid / 2 h / 100 °C
2: 91 percent / CH3COOH,(CH3CO)2O / 3 h / 100 °C
View Scheme
参考文献
Shachkus, A.A.; Degutite, R.Yu.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 8 p. 852 - 855
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , # 8 p. 1056 - 1059
反应条件
1: acetonitrile / 12 h / |Reflux
2: ethanol / 12 h / |Reflux; |Inert atmosphere
View Scheme
参考文献
Gu, Jiamin; Anumala, Upendra Rao; Lo Monte, Fabio; Kramer, Thomas; Heyny Von Haussen, Roland; Hoelzer, Jana; Goetschy-Meyer, Valerie; Mall, Gerhard; Hilger, Ingrid; Czech, Christian; Schmidt, Boris
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7667 - 7671
反应条件
in acetonitrile
30 h; RefluxInert atmosphere;
参考文献
Markova, Larysa I.; Malinovskii, Vladimir L.; Patsenker, Leonid D.; Haener, Robert
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 45 p. 8944 - 8947
反应条件
1: 100 °C
2: piperidine / butan-2-one
View Scheme
参考文献
Liu, Dingbin; Chen, Wenwen; Sun, Kang; Deng, Ke; Zhang, Wei; Wang, Zhuo; Jiang, Xingyu
Angewandte Chemie - International Edition, 2011 , vol. 50, # 18 p. 4103 - 4107
