5-羟基-4-十二碳烯酸-6-内酯合成路线 （共 8 条）
反应条件
in neat (no solvent)
T=120°C; P=0.05 - 0.1 Torr; 2 h;
参考文献
Pohmakotr, Manat; Jarupan, Prapanpong
Tetrahedron Letters, 1985 , vol. 26, # 18 p. 2253 - 2256
反应条件
Grubb's 2nd generation catalyst in toluene
1.5 h; RefluxInert atmosphere;
参考文献
Wickel, Susanne M.; Citron, Christian A.; Dickschat, Jeroen S.
European Journal of Organic Chemistry, 2013 , # 14 p. 2906 - 2913
反应条件
silver nitrate; copper(II) sulfate in water
T=60°C; 3 h; Title compound not separated from byproducts;
参考文献
Ogibin, Yu. N.; Troyanskii, E. I.; Kadentsev, V. I.; Lubuzh, E. D.; Chizhov, O. S.; Nikishin, G. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 5 p. 830 - 834
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 5 p. 1070 - 1075
反应条件
1: triethylamine / 20 °C / |Cooling with ice; |Inert atmosphere
2: Grubb's 2nd generation catalyst / toluene / 1.5 h / |Reflux; |Inert atmosphere
View Scheme
参考文献
Wickel, Susanne M.; Citron, Christian A.; Dickschat, Jeroen S.
European Journal of Organic Chemistry, 2013 , # 14 p. 2906 - 2913
反应条件
1: tetrakis(triphenylphosphine) palladium(0); diethylzinc / hexane / 4 h / 20 °C
2: triethylamine / 20 °C / |Cooling with ice; |Inert atmosphere
3: Grubb's 2nd generation catalyst / toluene / 1.5 h / |Reflux; |Inert atmosphere
View Scheme
参考文献
Wickel, Susanne M.; Citron, Christian A.; Dickschat, Jeroen S.
European Journal of Organic Chemistry, 2013 , # 14 p. 2906 - 2913
反应条件
1: tetrahydrofuran / -78 °C
2: pyridine
3: NaIO4 / methanol; H2O
4: 1.) LDA; 2.) glacial acetic acid / 1.) THF, -78 to RT, 10 h; 2.) THF, RT, 1 h
5: 80 percent / neat (no solvent) / 2 h / 120 °C / 0.05 - 0.1 Torr
View Scheme
参考文献
Pohmakotr, Manat; Jarupan, Prapanpong
Tetrahedron Letters, 1985 , vol. 26, # 18 p. 2253 - 2256
反应条件
1: pyridine
2: NaIO4 / methanol; H2O
3: 1.) LDA; 2.) glacial acetic acid / 1.) THF, -78 to RT, 10 h; 2.) THF, RT, 1 h
4: 80 percent / neat (no solvent) / 2 h / 120 °C / 0.05 - 0.1 Torr
View Scheme
参考文献
Pohmakotr, Manat; Jarupan, Prapanpong
Tetrahedron Letters, 1985 , vol. 26, # 18 p. 2253 - 2256
反应条件
1: 1.) LDA; 2.) glacial acetic acid / 1.) THF, -78 to RT, 10 h; 2.) THF, RT, 1 h
2: 80 percent / neat (no solvent) / 2 h / 120 °C / 0.05 - 0.1 Torr
View Scheme
参考文献
Pohmakotr, Manat; Jarupan, Prapanpong
Tetrahedron Letters, 1985 , vol. 26, # 18 p. 2253 - 2256
