(S)-3-氯-1-(噻吩-2-基)丙烷-1-醇合成路线 （共 8 条）
反应条件
1: With (S)-P-Phos; phenyl silane; copper (II) acetate monohydrate in toluene T=-20 - 20°C; 48 h; 2: With hydrogenchloride in water; toluene Reagent/catalyst; enantioselective reaction;
参考文献
Zhou, Ji-Ning; Fang, Qiang; Hu, Yi-Hu; Yang, Li-Yao; Wu, Fei-Fei; Xie, Lin-Jie; Wu, Jing; Li, Shijun
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 6 p. 1009 - 1017
反应条件
Novozyme in hexane T=30°C; 22 h; Enzymatic reaction;
参考文献
Cashman, John R.; Ghirmai, Senait
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 19 p. 6890 - 6897
反应条件
succinic acid anhydride; lipase in tert-butyl methyl ether T=20°C; 20 h;
参考文献
BASF Aktiengesellschaft
Patent: WO2005/73215 A1, 2005 ;
Location in patent: Page/Page column 4 ;
反应条件
1: NaI / acetone 2: tetrahydrofuran 3: NaH; DMA View Scheme
参考文献
Zhou, Ji-Ning; Fang, Qiang; Hu, Yi-Hu; Yang, Li-Yao; Wu, Fei-Fei; Xie, Lin-Jie; Wu, Jing; Li, Shijun
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 6 p. 1009 - 1017
反应条件
1: NaI / acetone 2: tetrahydrofuran 3: NaH; DMA View Scheme
参考文献
Zhou, Ji-Ning; Fang, Qiang; Hu, Yi-Hu; Yang, Li-Yao; Wu, Fei-Fei; Xie, Lin-Jie; Wu, Jing; Li, Shijun
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 6 p. 1009 - 1017
反应条件
1: NaI / acetone 2: tetrahydrofuran View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 13, # 24 p. 4477 - 4480
反应条件
in methanol; water T=75°C; 20 h;
参考文献
WO2005/73215 A1, ;
Page/Page column 4 ;
反应条件
sodium iodide in acetone
Heating;
参考文献
Wheeler; Kuo
Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 3 p. 213 - 223
