trifluoroacetic acid in dichloromethane T=0 - 20°C; 32 h;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '7639305', constants.ctx, '0')">N-(tert-butyloxycarbonyl)-3-methoxy-2-methylaniline</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587206', constants.ctx, '0')">sec.-butyllithium</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1900225', constants.ctx, '0')">cyclohexane</a> <br />T=-50 - -20&deg;C;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '3600878', constants.ctx, '0')">N,O-dimethylacetohydroxamic acid</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1900225', constants.ctx, '0')">cyclohexane</a> <br />T=-60 - 15&deg;C;&nbsp;2&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 73 percent / tetrahydrofuran / 2 h / Heating<br />2: 1.) s-BuLi / 1.) cyclohexanone, THF, -40 deg C, 0.25 h, 2.) cyclohexanone, THF, from -40 deg C to RT, 2 h<br /> <br /> &nbsp;