(S)-2-氨基-2-乙基己酸乙酯合成路线 （共 9 条）
反应条件
porcine liver esterase in phosphate buffer T=30°C; Hydrolysis; resolution of racemate; pH=8.0; 7.5 h;
参考文献
Imawaka, Naoto; Tanaka, Masakazu; Suemune, Hiroshi
Helvetica Chimica Acta, 2000 , vol. 83, # 10 p. 2823 - 2835
反应条件
1: H2SO4 / Heating 2: 31 percent / porcine liver esterase / aq. phosphate buffer / 7.5 h / 30 °C / pH 8.0 View Scheme
参考文献
Imawaka, Naoto; Tanaka, Masakazu; Suemune, Hiroshi
Helvetica Chimica Acta, 2000 , vol. 83, # 10 p. 2823 - 2835
反应条件
1: NH4Cl / H2O; ethanol / 48 h / 55 - 60 °C 2: conc. HCl / 24 h / 80 °C 3: H2SO4 / Heating 4: 31 percent / porcine liver esterase / aq. phosphate buffer / 7.5 h / 30 °C / pH 8.0 View Scheme
参考文献
Imawaka, Naoto; Tanaka, Masakazu; Suemune, Hiroshi
Helvetica Chimica Acta, 2000 , vol. 83, # 10 p. 2823 - 2835
反应条件
1: conc. HCl / 24 h / 80 °C 2: H2SO4 / Heating 3: 31 percent / porcine liver esterase / aq. phosphate buffer / 7.5 h / 30 °C / pH 8.0 View Scheme
参考文献
Imawaka, Naoto; Tanaka, Masakazu; Suemune, Hiroshi
Helvetica Chimica Acta, 2000 , vol. 83, # 10 p. 2823 - 2835
反应条件
1: 85 percent / lithium diisopropylamine / tetrahydrofuran / 10 h / Ambient temperature 2: 94 percent / aq. HCl / 1 h / Ambient temperature 3: Humicola amino esterase, phosphate buffer, pH 7.5 / Ambient temperature View Scheme
参考文献
Liu, Weiguo; Ray, Paul; Benezra, Steven A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 5 p. 553 - 560
反应条件
1: 98 percent / Et3N / toluene / Heating 2: 85 percent / lithium diisopropylamine / tetrahydrofuran / 10 h / Ambient temperature 3: 94 percent / aq. HCl / 1 h / Ambient temperature 4: Humicola amino esterase, phosphate buffer, pH 7.5 / Ambient temperature View Scheme
参考文献
Liu, Weiguo; Ray, Paul; Benezra, Steven A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 5 p. 553 - 560
反应条件
phosphate buffer; Humicola amino esterase Ambient temperature;
参考文献
Liu, Weiguo; Ray, Paul; Benezra, Steven A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 5 p. 553 - 560
反应条件
1: 94 percent / aq. HCl / 1 h / Ambient temperature 2: Humicola amino esterase, phosphate buffer, pH 7.5 / Ambient temperature View Scheme
参考文献
Liu, Weiguo; Ray, Paul; Benezra, Steven A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 5 p. 553 - 560
反应条件
sodium hydroxide in water T=20 - 50°C; Hydrolysis; 21 h;
参考文献
Imawaka, Naoto; Tanaka, Masakazu; Suemune, Hiroshi
Helvetica Chimica Acta, 2000 , vol. 83, # 10 p. 2823 - 2835
