1: 93 percent / Mg(0) / methanol; benzene / 25 °C 2: 72 percent / DIBAL-H / toluene / -78 °C 3: 85 percent / KHMDS / tetrahydrofuran / -20 °C 4: Bu4NF / tetrahydrofuran / 23 °C View Scheme

1: 93 percent / Mg(0) / methanol; benzene / 25 °C 2: 72 percent / DIBAL-H / toluene / -78 °C 3: 85 percent / KHMDS / tetrahydrofuran / -20 °C 4: Bu4NF / tetrahydrofuran / 23 °C 5: 82 percent / OsO4, (DHQD)2PYDZ / H2O; 2-methyl-propan-2-ol / 52 h / 0 °C 6: pyridine / CH2Cl2 / 23 °C 7: K2CO3 / methanol 8: n-BuLi / tetrahydrofuran / -20 °C View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: DIBAL-H<br />2: Swern oxidn. / -40 &deg;C<br />3: 85 percent / LiCl, DBU / CH₂Cl₂; acetonitrile<br /> <br /> &nbsp;