1-氟-4-[(4-甲基苯基)磺酰基]苯合成路线 （共 10 条）
反应条件
9,9-dimethyl-4,6-bis(diphenylphosphino)xanthene; tetrabutyl-ammonium chloride; caesium carbonate; tris(dibenzylideneacetone)dipalladium (0) in toluene
T=80°C; 1 h;
参考文献
Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Parisi, Luca M.
Organic Letters, 2002 , vol. 4, # 26 p. 4719 - 4721
反应条件
potassium hydroxide; HF in o-di-fluorobenzene; water
参考文献
Rhone-Poulenc Specialites Chimiques
Patent: US4554381 A1, 1985 ;
反应条件
copper; isopentyl nitrite in acetonitrile
T=0 - 25°C; Sandmeyer Reaction; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Yang, Xiaobo; Shi, Liangliang; Fu, Hua
Synlett, 2014 , vol. 25, # 6 art. no. 677, p. 847 - 852
反应条件
tetrabutyl-ammonium chloride; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; tris(dibenzylideneacetone)dipalladium (0) in toluene
T=120°C; 19 h;
参考文献
Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Parisi, Luca M.; Bernini, Roberta
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5608 - 5614
反应条件
anhydrous magnesium perchlorate
4.5 h; Heating;
参考文献
Bandgar; Kamble; Bavikar
Journal of Chemical Research - Part S, 2003 , # 5 p. 287 - 289
反应条件
copper diacetate; 1-(n-butyl)-3-methylimidazolium triflate
T=20°C; 12 h;
参考文献
Kantam, M. Lakshmi; Neelima; Sreedhar; Chakravarti, Rajashree
Synlett, 2008 , # 10 p. 1455 - 1458
反应条件
PEG-400
T=50°C; 0.166667 h; Microwave irradiationSealed tube;
参考文献
Kumar, Dalip; Arun; Pilania, Meenakshi; Shekar, K.P. Chandra
Synlett, 2013 , vol. 24, # 7 art. no. ST-2013-D0144-L, p. 831 - 836
反应条件
bismuth trifluoromethanesulphonate
T=120°C; sulfonylation; 1.5 h; Title compound not separated from byproducts;
参考文献
Repichet, Sigrid; Le Roux, Christophe; Hernandez, Pierre; Dubac, Jacques; Desmurs, Jean-Roger
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6479 - 6482
反应条件
1: hydrogenchloride / water / pH 2 - 3 / |Inert atmosphere
2: copper; isopentyl nitrite / acetonitrile / 12 h / 0 - 25 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Yang, Xiaobo; Shi, Liangliang; Fu, Hua
Synlett, 2014 , vol. 25, # 6 art. no. 677, p. 847 - 852
反应条件
aluminium trichloride
参考文献
Effenberger,F.; Gleiter,R.
Chemische Berichte, 1964 , vol. 97, p. 472 - 479
