[(4-羟基-2-喹唑啉基)硫基]乙酸合成路线 （共 7 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; Inert atmosphere;
参考文献
AMGEN INC.; BREGMAN, Howard; BUCHANAN, John L.; CHAKKA, Nagasree; DIMAURO, Erin F.; GUNAYDIN, Hakan; GUZMAN PEREZ, Angel; HUA, Zihao; HUANG, Xin
Patent: WO2014/36022 A1, 2014 ;
Location in patent: Paragraph 0182 ;
反应条件
potassium hydroxide in ethanol
参考文献
Yun, L. M.; Yangibaev, S.; Shakhidoyatov, Kh. M.; Alekseeva, V. Ya.; V'yunov, K. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 2 p. 214 - 216
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , vol. 23, # 2 p. 254 - 256
反应条件
water in acetonitrile Substitution; cyclization; 3 h; Heating;
参考文献
Gruner, Margit; Rehwald, Matthias; Eckert, Katrin; Gewald, Karl
Heterocycles, 2000 , vol. 53, # 11 p. 2363 - 2377
反应条件
potassium carbonate in water 1 h; Reflux;
参考文献
Reddy, B. Srinivasa; Naidu; Dubey
Phosphorus, Sulfur and Silicon and the Related Elements, 2012 , vol. 187, # 5 p. 598 - 605
反应条件
1: potassium carbonate / acetone / 7 h / 20 °C / |Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 20 °C / |Inert atmosphere View Scheme
参考文献
AMGEN INC.; BREGMAN, Howard; BUCHANAN, John L.; CHAKKA, Nagasree; DIMAURO, Erin F.; GUNAYDIN, Hakan; GUZMAN PEREZ, Angel; HUA, Zihao; HUANG, Xin
Patent: WO2014/36022 A1, 2014 ;
反应条件
1: dioxane / 2 h 2: 80 percent / water / acetonitrile / 3 h / Heating View Scheme
参考文献
Gruner, Margit; Rehwald, Matthias; Eckert, Katrin; Gewald, Karl
Heterocycles, 2000 , vol. 53, # 11 p. 2363 - 2377
反应条件
pyridine; acetic anhydride
0.5 h; Heating;
参考文献
Chaurasia, Munnu Ram; Sharma, Ajay Kumar
Heterocycles, 1983 , vol. 20, # 8 p. 1549 - 1558
