potassium carbonate in N,N-dimethyl-formamide T=20°C;

2,2''-bis[1-(dialkylphosphino)ethyl]1,1''-biferrocene; hydrogen; bis(norbornadiene)rhodium(I) hexafluorophosphate in 1,2-dichloro-ethane T=50°C; Hydrogenation; P=735.508 Torr; 24 h;

1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether; cyclohexane T=-78°C; 3 h; Inert atmosphere; 2: With C12H24N2O(2-)*2Li(1+) in diethyl ether; cyclohexane T=-45°C; 3 h; Inert atmosphere; 3: methyl chloroformate in diethyl ether; cyclohexane T=-78°C; 2 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

1: 1-(tert-butoxy-carbonyl)piperidine With sec.-butyllithium; (+)-sparteine surrogate in hexanes; diethyl ether T=-78 - -20°C; Inert atmosphere; 2: methyl chloroformate in hexanes; diethyl ether T=-78 - 20°C; Inert atmosphere; optical yield given as percent ee;

1: N-Boc-2-(tributylstannyl)piperidine With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; Inert atmosphere; 2: methyl chloroformate in tetrahydrofuran; hexanes T=-78 - 20°C; Inert atmosphere; optical yield given as percent ee;

1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium chlorite; sodium hypochlorite / acetonitrile; aq. phosphate buffer / 24 h / 20 °C / pH 6.8 / |Inert atmosphere 2: diethyl ether / 0 °C / |Inert atmosphere View Scheme

in diethyl ether T=0°C; Inert atmosphere;

1: 1-(tert-butoxy-carbonyl)piperidine With sec.-butyllithium; (+)-sparteine surrogate in hexanes; diethyl ether T=-78°C; 6 h; Inert atmosphere; 2: dimethyl(phenyl)silyl chloride in hexanes; diethyl ether T=-78 - 40°C; Inert atmosphere; 3: methyl chloroformate in hexanes; diethyl ether T=-40 - 20°C; Inert atmosphere; optical yield given as percent ee;

in methanol; hexanes; toluene T=0 - 20°C; Inert atmosphere; optical yield given as percent ee;

1: With diisobutylaluminium hydride in toluene T=-78°C; 0.666667 h; 2: With methanol in toluene T=-78°C; 0.166667 h;