4-(三氟甲基)异硫氰酸苯酯合成路线 （共 15 条）
反应条件
in methanol; water 4 h; Reflux;
参考文献
He, Xiao-Yang; Zou, Peng; Qiu, Jiayin; Hou, Ling; Jiang, Shibo; Liu, Shuwen; Xie, Lan
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 22 p. 6726 - 6734
反应条件
1: in acetonitrile T=20°C; 0.333333 h; 2: With 2-chloro-1-methyl-pyridinium iodide; triethylamine in acetonitrile T=50°C; 5 h; Product distribution / selectivity;
参考文献
Novartis AG
Patent: US2007/49622 A1, 2007 ;
Location in patent: Page/Page column 41 ;
反应条件
in N,N-dimethyl-formamide 0.5 h; Ambient temperature;
参考文献
Blumenkopf; Harrington; Koble; Bankston; Morrison Jr.; Bigham; Styles; Spector
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2306 - 2314
反应条件
hydrazine in water; isopropyl alcohol T=20°C; 0.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 8 p. 3048 - 3064
反应条件
ammonia in water; acetone T=25 - 35°C; 6 h;
参考文献
Jamir, Latonglila; Sinha, Upasana Bora; Nath, Jayashree; Patel, Bhisma K.
Synthetic Communications, 2012 , vol. 42, # 7 p. 951 - 958
