2-甲氧基-4-甲基-5-溴吡啶合成路线 （共 6 条）
反应条件
silver carbonate in benzene T=60°C; 3 h;
参考文献
Pearson, Neil D.; Broom, Nigel J.P.; O'Hanlon, Peter J.
Tetrahedron Letters, 1994 , vol. 35, # 22 p. 3771 - 3774
反应条件
disodium hydrogenphosphate; bromine in water T=20°C; 4.25 h;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 9 p. 3084 - 3092
反应条件
1: 1.) NaNO2, 20 percent sulphuric acid / 1.) 0 deg C, 1 h; 2.) 1 h, reflux 2: 74 percent / silver carbonate / benzene / 3 h / 60 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 22 p. 3771 - 3774
反应条件
potassium acetate; palladium diacetate in N,N-dimethyl-formamide T=90°C; 3 h; Product distribution / selectivity;
参考文献
US2008/318943 A1, ;
Page/Page column 73; 75 ;
US 20080318943 A1
反应条件
n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-100 - 20°C; 20.5 h;
参考文献
Arvanitis, Argyrios G; Arnold, Charles R; Fitzgerald, Lawrence W; Frietze, William E; Olson, Richard E; Gilligan, Paul J; Robertson, David W
Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 289 - 291
反应条件
1: 5-bromo-2-methoxy-4-methylpyridine With n-butyllithium in tetrahydrofuran; hexanes T=-70°C; 0.666667 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexanes T=-70 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; hexanes; water
参考文献
ASTRAZENECA AB
Patent: WO2006/65215 A1, 2006 ;
Location in patent: Page/Page column 19; 35 ;
WO 2006/065215 A1
