3-甲氧基-4-甲基苯胺合成路线 (共 16 条)
反应条件
iron; acetic acid T=45°C; 3.5 h; Inert atmosphere;
参考文献
Hesse, Ronny; Gruner, Konstanze K.; Kataeva, Olga; Schmidt, Arndt W.; Knoelker, Hans-Joachim
Chemistry - A European Journal, 2013 , vol. 19, # 42 p. 14098 - 14111
反应条件
in ethanol; ethyl acetate
参考文献
Pfahl, Magnus; Tachdjian, Catherine; Spruce, Lyle W.; Al-Shamma, Hussien A.; Boudjelal, Mohamed; Fanjul, Andrea N.; Wiemann, Torsten R.; Pleynet, David P.M.
Patent: US2003/144329 A1, 2003 ;
反应条件
ammonia; sodium amide
参考文献
Journal of the American Chemical Society, , vol. 74, p. 3011,3012
反应条件
1: aqueous KOH 2: liquid ammonia; NaNH2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 74, p. 3011,3012
反应条件
sodium sulfide; sodium hydroxide; sulfur
参考文献
Chemische Berichte, , vol. 84, p. 557,561
参考文献
Journal of the American Chemical Society, , vol. 74, p. 3011,3012
反应条件
1: (i) aq. NH2OH*HCl, NaOAc, (ii) CuSO4, Na2SO3, aq. NaOAc, (iii) /BRN= 742602/, NaNO2, aq. HCl 2: aq. HNO3 3: aq. AgNO3, NaOH View Scheme
参考文献
Tsuda,K. et al.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, p. 856 - 865
反应条件
(i) (diazotization), (ii) (hydrolysis); Multistep reaction;
参考文献
AUTIFONY THERAPEUTICS LIMITED; ALVARO, Giuseppe; DAMBRUOSO, Paolo; MARASCO, Agostino; TOMMASI, Simona; DECOR, Anne; LARGE, Charles
Patent: WO2012/76877 A1, 2012 ;
Location in patent: Page/Page column 222 ;
WO 2012/076877 A1
反应条件
1: With sulfuric acid; sodium nitrite in water T=0°C; 0.5 h; 2: With urea in water T=0°C; 0.5 h; 3: With potassium iodide in water T=20°C; 1 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/48334 A1, 2004 ;
Location in patent: Page 159-163 ;
WO 2004/048334 A1
反应条件
1: palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; caesium carbonate / toluene / 26 h / 100 °C 2: palladium diacetate; potassium carbonate; 2,2,2-trimethylacetic acid / 24 h / 100 °C 3: boron tribromide / dichloromethane / 15.5 h / -78 - 20 °C View Scheme
参考文献
Hesse, Ronny; Gruner, Konstanze K.; Kataeva, Olga; Schmidt, Arndt W.; Knoelker, Hans-Joachim
Chemistry - A European Journal, 2013 , vol. 19, # 42 p. 14098 - 14111