5-羟基-2-苯并呋喃羧酸甲酯合成路线 （共 9 条）
反应条件
1: With boron tribromide in dichloromethane T=-40 - 20°C; 2: With methanol in dichloromethane 3: With thionyl chloride; water more than 3 stages;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2005/118584 A2, 2005 ;
Location in patent: Page/Page column 65 ;
反应条件
PS 4-(methylazoamino)phenoxymethyl resin in dichloromethane T=20°C; 2 h;
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; LI, Xiaodong; KARANEWSKY, Donald S.; FOTSING, Joseph; PATRON, Andrew; DARMOHUSODO, Vincent; SELCHAU, Victor; CHING, Brett
Patent: WO2011/159781 A2, 2011 ;
Location in patent: Page/Page column 67 ;
WO 2011/159781 A2
反应条件
1: 5-methoxy-benzofuran-2-carboxylic acid methyl ester With boron tribromide in dichloromethane T=-40 - 20°C; 17 h; 2: methanol With thionyl chloride T=0°C; 72 h;
参考文献
AXYS PHARMACEUTICALS INC.
Patent: WO2004/92115 A2, 2004 ;
Location in patent: Page 78 ;
WO 2004/092115 A2
反应条件
thionyl chloride 24 h;
参考文献
Martin; Winkler
Helvetica Chimica Acta, 1994 , vol. 77, # 1 p. 100 - 110
反应条件
1.1: 41 percent / K2CO3 / dimethylformamide / 20 - 80 °C 2.1: BBr3 / CH2Cl2 / -15 - 20 °C 2.2: 76 percent / SOCl2 / methanol / 20 - 70 °C View Scheme
参考文献
Martin; Winkler
Helvetica Chimica Acta, 1994 , vol. 77, # 1 p. 100 - 110
反应条件
boron tribromide in dichloromethane 18 h;
参考文献
Martin; Winkler
Helvetica Chimica Acta, 1994 , vol. 77, # 1 p. 100 - 110
反应条件
in benzene T=120°C; Diels-Alder reaction; 72 h;
参考文献
Rosa, Claudia Della; Kneeteman, Maria N.; Mancini, Pedro M.E.
Tetrahedron Letters, 2005 , vol. 46, # 50 p. 8711 - 8714
反应条件
1: boron tribromide / dichloromethane / -78 - 20 °C 2: PS 4-(methylazoamino)phenoxymethyl resin / dichloromethane / 2 h / 20 °C View Scheme
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; LI, Xiaodong; KARANEWSKY, Donald S.; FOTSING, Joseph; PATRON, Andrew; DARMOHUSODO, Vincent; SELCHAU, Victor; CHING, Brett
Patent: WO2011/159781 A2, 2011 ;
WO 2011/159781 A2
反应条件
1: boron tribromide / dichloromethane / 0.75 h / -15 °C 2: thionyl chloride / 1 h / 80 °C View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157270 A1, 2008 ;
