1-溴-2,3,5,6-四甲基苯合成路线 （共 25 条）
反应条件
1: AlCl3 2: (i) HF, (ii) (heating) 3: (i) Mg, (ii) aq. H2SO4 View Scheme
参考文献
Yagupol'skii,L.M.; Matyushecheva,G.I.
J. Gen. Chem. USSR (Engl. Transl.), 1965 , vol. 35, p. 1422 - 1426,1426 - 1429
反应条件
aluminium trichloride
参考文献
Yagupol'skii,L.M.; Matyushecheva,G.I.
J. Gen. Chem. USSR (Engl. Transl.), 1965 , vol. 35, p. 1422 - 1426,1426 - 1429
反应条件
sulfuric acid T=25 - 30°C;
参考文献
Smith; Moyle
Journal of the American Chemical Society, 1933 , vol. 55, p. 1676,1681
参考文献
Smith; Moyle
Journal of the American Chemical Society, 1933 , vol. 55, p. 1676,1681
反应条件
pyridine; copper(II) sulfate
T=230°C;
参考文献
Fuson et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 5321
反应条件
1: concentrated H2SO4; chloroform; HNO3
2: tin; aqueous hydrochloric acid
View Scheme
参考文献
Birtles; Hampson
Journal of the Chemical Society, 1937 , p. 10,14
Full Text Show Details
Smith; Horner
Journal of the American Chemical Society, 1940 , vol. 62, p. 1349,1353
反应条件
1: 1.) n-BuLi / 1.) diethyl ether, n-hexane, reflux, 2.) diethyl ether, n-hexane, reflux, overnight
2: N2O4, sodium acetate / CCl4 / 1 h / 5 - 10 °C
3: LiAlH4 / diethyl ether / -30 - -10 °C
4: oxygen / benzene / 20 °C / Irradiation
View Scheme
参考文献
Coops et al.
Recueil des Travaux Chimiques des Pays-Bas, 1940 , vol. 59, p. 1109,1111
反应条件
1: magnesium; diethyl ether; benzene / Einleiten von Kohlendioxid in die Reaktionsloesung
2: thionyl chloride
View Scheme
参考文献
Fuson; Kelton
Journal of the American Chemical Society, 1941 , vol. 63, p. 1500
Full Text View citing articles Show Details
Coops et al.
Recueil des Travaux Chimiques des Pays-Bas, 1940 , vol. 59, p. 1109,1111
反应条件
pyridine; potassium permanganate in water
13 h; Heating;
参考文献
Holy, Petr; Sehnal, Petr; Tichy, Milos; Zavada, Jiri; Cisarova, Ivana
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3805 - 3810
反应条件
1: 80 percent / pyridine; potassium permanganate / H2O / 13 h / Heating
2: thionyl chloride; N,N-dimethylformamide / 8 h / Heating
3: 1 h / Heating
View Scheme
参考文献
Holy, Petr; Sehnal, Petr; Tichy, Milos; Zavada, Jiri; Cisarova, Ivana
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3805 - 3810
