2,4-二氨基嘧啶-5-腈合成路线 （共 14 条）
反应条件
1: 1-methylguanidine hydrochloride With sodium ethanolate 0.166667 - 0.25 h; Reflux; 2: (ethoxymethylene)malononitrile T=20°C; 8 h;
参考文献
Karoli, Tomislav; Mamidyala, Sreeman K.; Zuegg, Johannes; Fry, Scott R.; Tee, Ernest H.L.; Bradford, Tanya A.; Madala, Praveen K.; Huang, Johnny X.; Ramu, Soumya; Butler, Mark S.; Cooper, Matthew A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2428 - 2433
反应条件
hydrogenchloride; anhydrous sodium hydrogen carbonate in water; acetic acid; acetone
参考文献
Burroughs Wellcome Co.
Patent: US4116958 A1, 1978 ;
反应条件
1: GNO3 With sodium ethanolate in ethanol Reflux; 2: (ethoxymethylene)malononitrile in ethanol T=10°C;
参考文献
Bag, Seema; Tawari, Nilesh R.; Degani, Mariam S.; Queener, Sherry F.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 9 p. 3187 - 3197
反应条件
ammonia T=60°C; 0.333333 h;
参考文献
Schmidt, Hans-Werner; Koitz, Gerald; Junek, Hans
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1305 - 1307
反应条件
1: 71 percent / conc.aq.HCl / 0.33 h 2: 76 percent / NH3 / 0.33 h / 60 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 1305 - 1307
参考文献
Yakugaku Zasshi, , vol. 62, p. 417,443;dtsch.Ref.S.122,125
Chem.Abstr., , p. 4724
参考文献
Chemische Berichte, , vol. 71, p. 87,99
Journal of the American Chemical Society, , vol. 65, p. 2222,2224
Journal of the American Chemical Society, , vol. 66, p. 876,877
反应条件
1: H2; aq. HCl / Pd/C / 3 h / 60 °C / 3150.25 Torr 2: aq. NaBH4 View Scheme
参考文献
Otzen, Thomas; Wempe, Ellen G.; Kunz, Brigitte; Bartels, Rainer; Lehwark-Yvetot, Gudrun; Haensel, Wolfram; Schaper, Klaus-Juergen; Seydel, Joachim K.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 240 - 253
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; 2 h;
参考文献
Karoli, Tomislav; Mamidyala, Sreeman K.; Zuegg, Johannes; Fry, Scott R.; Tee, Ernest H.L.; Bradford, Tanya A.; Madala, Praveen K.; Huang, Johnny X.; Ramu, Soumya; Butler, Mark S.; Cooper, Matthew A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2428 - 2433
反应条件
ammonia; nickel Hydrogenation;
参考文献
Huber
Journal of the American Chemical Society, 1943 , vol. 65, p. 2222,2224
Journal of the American Chemical Society, 1944 , vol. 66, p. 876,877
Full Text Show Details
Tieckelmann et al.
Journal of Organic Chemistry, 1960 , vol. 25, p. 1257
