5-溴-2,3-二甲氧基苯甲腈合成路线 （共 9 条）
反应条件
trichlorophosphate in benzene 10 h; Heating;
参考文献
Tiwari, Shashi B.; Kohli
Medicinal Chemistry Research, 2008 , vol. 17, # 2-7 p. 386 - 398
反应条件
sodium acetate; ammonium chloride in formic acid 4 h; Heating;
参考文献
Thurkauf, Andrew; Hutchison, Alan; Peterson, John; Cornfield, Linda; Meade, Robin; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2251 - 2255
反应条件
1: 62 percent / K2CO3 / dimethylformamide / 4 h / Ambient temperature 2: 7.4 g / NH4OH*HCl, NaOAc / formic acid / 4 h / Heating View Scheme
参考文献
Thurkauf, Andrew; Hutchison, Alan; Peterson, John; Cornfield, Linda; Meade, Robin; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2251 - 2255
反应条件
1: 55 percent / N-bromosuccinimide / acetone; H2O / 0.33 h 2: 62 percent / K2CO3 / dimethylformamide / 4 h / Ambient temperature 3: 7.4 g / NH4OH*HCl, NaOAc / formic acid / 4 h / Heating View Scheme
参考文献
Thurkauf, Andrew; Hutchison, Alan; Peterson, John; Cornfield, Linda; Meade, Robin; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2251 - 2255
反应条件
1: 88 percent / Br2 / acetic acid / 20 °C 2: 86 percent / potassium carbonate / acetone / Heating 3: 95 percent / thionyl chloride / benzene / Heating 4: 100 percent / Et3N / CH2Cl2 / 20 °C 5: 88 percent / POCl3 / benzene / 10 h / Heating View Scheme
参考文献
Huang, Yunsheng; Luedtke, Robert R.; Freeman, Rebekah A.; Wu, Li; Mach, Robert H.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3113 - 3122
反应条件
1: 95 percent / thionyl chloride / benzene / Heating 2: 100 percent / Et3N / CH2Cl2 / 20 °C 3: 88 percent / POCl3 / benzene / 10 h / Heating View Scheme
参考文献
Huang, Yunsheng; Luedtke, Robert R.; Freeman, Rebekah A.; Wu, Li; Mach, Robert H.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3113 - 3122
反应条件
1: 86 percent / potassium carbonate / acetone / Heating 2: 95 percent / thionyl chloride / benzene / Heating 3: 100 percent / Et3N / CH2Cl2 / 20 °C 4: 88 percent / POCl3 / benzene / 10 h / Heating View Scheme
参考文献
Huang, Yunsheng; Luedtke, Robert R.; Freeman, Rebekah A.; Wu, Li; Mach, Robert H.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3113 - 3122
反应条件
1: 100 percent / Et3N / CH2Cl2 / 20 °C 2: 88 percent / POCl3 / benzene / 10 h / Heating View Scheme
参考文献
Huang, Yunsheng; Luedtke, Robert R.; Freeman, Rebekah A.; Wu, Li; Mach, Robert H.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3113 - 3122
参考文献
Fuson; Gaertner; Chadwick
Journal of Organic Chemistry, 1948 , vol. 13, p. 489,493
