3,3-二甲基-1-溴丁烷 [1647-23-0]合成路线 （共 26 条）
反应条件
cyanide anion; lt;Pgt;-(CH2)3-+PBu3 in water T=110°C; 1.1 h;
参考文献
Chiles, Margaret Shea; Jackson, Donald D.; Reeves, Perry C.
Journal of Organic Chemistry, 1980 , vol. 45, # 14 p. 2915 - 2918
反应条件
in dimethyl sulfoxide
参考文献
Yokohama; Miwa; Aibara; Fujiwara; Matsumoto; Nakayama; Iwamoto; Mori; Moroi; Tsukada; Isoda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 9 p. 2391 - 2398
反应条件
ammonia T=106 - 120°C; P=51485.6 - 66195.7 Torr;
参考文献
Howe; Hass
Industrial and Engineering Chemistry, 1946 , vol. 38, p. 252
反应条件
1: 1.) n-butyllithium, 2.) hexamethylphosphoric triamide (HMPA) / 1.) hexane, diethyl ether, -70 deg C, 25 min, 2.) hexane, diethyl, RT, 2 h
2: 84 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.67 h / Heating
View Scheme
参考文献
Hsiao, C.-N.; Shechter, H.
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2688 - 2699
反应条件
1.1: Mg / diethyl ether / 2 h / 20 °C
1.2: 43.9 percent / diethyl ether / 1 h / 20 °C
2.1: 44.8 percent / LiAlH4 / diethyl ether / 5 h / Heating
3.1: 54.4 percent / PBr3; pyridine / 12 h / Heating
View Scheme
参考文献
Hamano, Hiroshi; Nagata, Keiichi; Fukada, Nobuo; Shimotahira, Hiroshi; Ju, Xiu-Lian; Ozoe, Yoshihisa
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 665 - 674
反应条件
1: Na / ethanol / Heating
2: aq. KOH
3: 180 °C / (thermolysis)
View Scheme
参考文献
Bianchi,M. et al.
Gazzetta Chimica Italiana, 1974 , vol. 104, p. 273 - 286
