palladium T=160°C;

<b>Multi-step reaction with 4 steps<br /> </b>1: Pd(dba)2; Ph₃As; CuI / 1-methyl-pyrrolidin-2-one / 10 h / 50 &deg;C<br />2: 380 mg / Pd(OAc)2; PPh₃; CO / acetonitrile / 15 h / 70 &deg;C / 3040 Torr<br />3: 81 percent / NaH / tetrahydrofuran / 4 h / 0 &deg;C<br />4: 100 percent / H₂ / Pd(OH)2/C / methanol / 15 h / 20 &deg;C / 1900 Torr<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: Pd(PPh₃)2Cl₂; CuI / 1-methyl-pyrrolidin-2-one / 10 h / 50 &deg;C<br />2: 380 mg / Pd(OAc)2; PPh₃; CO / acetonitrile / 15 h / 70 &deg;C / 3040 Torr<br />3: 81 percent / NaH / tetrahydrofuran / 4 h / 0 &deg;C<br />4: 100 percent / H₂ / Pd(OH)2/C / methanol / 15 h / 20 &deg;C / 1900 Torr<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 380 mg / Pd(OAc)2; PPh₃; CO / acetonitrile / 15 h / 70 &deg;C / 3040 Torr<br />2: 81 percent / NaH / tetrahydrofuran / 4 h / 0 &deg;C<br />3: 100 percent / H₂ / Pd(OH)2/C / methanol / 15 h / 20 &deg;C / 1900 Torr<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 81 percent / NaH / tetrahydrofuran / 4 h / 0 &deg;C<br />2: 100 percent / H₂ / Pd(OH)2/C / methanol / 15 h / 20 &deg;C / 1900 Torr<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: HMDS<br />2: Pd(dba)2; Ph₃As; CuI / 1-methyl-pyrrolidin-2-one / 10 h / 50 &deg;C<br />3: 380 mg / Pd(OAc)2; PPh₃; CO / acetonitrile / 15 h / 70 &deg;C / 3040 Torr<br />4: 81 percent / NaH / tetrahydrofuran / 4 h / 0 &deg;C<br />5: 100 percent / H₂ / Pd(OH)2/C / methanol / 15 h / 20 &deg;C / 1900 Torr<br /> <br /> &nbsp;