3-溴-N,N-二甲基苯胺合成路线 （共 26 条）
反应条件
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -78 °C / |Schlenk technique; |Inert atmosphere 1.2: 0.25 h / -78 °C / |Schlenk technique; |Inert atmosphere 2.1: potassium hydrogensulfate / anhydrous xylene / 1 h / 150 °C View Scheme
参考文献
Pastierik, Tomas; Sebej, Peter; Medalova, Jirina; Stacko, Peter; Klan, Petr
Journal of Organic Chemistry, 2014 , vol. 79, # 8 p. 3374 - 3382
反应条件
1: With magnesium in tetrahydrofuran 2 h; Heating; 2: With sulfur in tetrahydrofuran 2 h; Heating;
参考文献
Detty, Michael R.; Donnelly, David J.; Wagner, Stephen J.
Patent: US2006/40908 A1, 2006 ;
Location in patent: Page/Page column 7 ;
参考文献
Bordwell; Boutan
Journal of the American Chemical Society, 1956 , vol. 78, p. 87,90
反应条件
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -78 °C / |Schlenk technique; |Inert atmosphere 1.2: 0.25 h / -78 °C / |Schlenk technique; |Inert atmosphere 2.1: potassium hydrogensulfate / anhydrous xylene / 1 h / 150 °C 3.1: boron trichloride / dichloromethane / 0 °C / |Inert atmosphere 3.2: polyphosphoric acid / 3 h / 40 - 130 °C / |Inert atmosphere 4.1: potassium permanganate / acetone / 3 h / 0 °C View Scheme
参考文献
Pastierik, Tomas; Sebej, Peter; Medalova, Jirina; Stacko, Peter; Klan, Petr
Journal of Organic Chemistry, 2014 , vol. 79, # 8 p. 3374 - 3382
反应条件
tert.-butyl lithium 1.) THF, hexane, from -78 deg C to -70 deg C, 30 min, 2.) Et2O, THF, hexane, -78 deg C, 10 min; Multistep reaction;
参考文献
Nair, Haridasan K.; Lee, Keun; Quinn, Daniel M.
Journal of the American Chemical Society, 1993 , vol. 115, # 22 p. 9939 - 9941
参考文献
Salvador,R.L.; Saucier,M.
Tetrahedron, 1971 , vol. 27, p. 1221 - 1226
参考文献
Schmidt; Schumacher
Chemische Berichte, 1921 , vol. 54, p. 1417
参考文献
Schmidt; Schumacher
Chemische Berichte, 1921 , vol. 54, p. 1417
反应条件
1: With n-butyllithium; boric acid trimethyl ester in tetrahydrofuran; hexanes T=-78 - -20°C; 1.41667 h; 2: With hydrogenchloride in tetrahydrofuran; hexanes; water 0.0833333 h;
参考文献
US2006/270686 A1, ;
Page/Page column 26 ;
反应条件
n-butyllithium in ethanol
