1,2-二{2-[2-(2-甲氧基乙氧基)乙氧基]乙氧基}-4,5-二硝基苯合成路线 （共 3 条）
反应条件
nitric acid; acetic acid in water T=0 - 5°C; 0.5 - 1 h; Product distribution / selectivity;
参考文献
PHARMACYCLICS, INC.
Patent: WO2007/40506 A1, 2007 ;
Location in patent: Page/Page column 12-13 ;
反应条件
1: 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethanol With sodium hydride in ethylene glycol dimethyl ether; mineral oil T=20°C; 1 h; Inert atmosphere; 2: 1,2-dinitro-4,5-difluorobenzene in ethylene glycol dimethyl ether; mineral oil T=20°C; Inert atmosphere;
参考文献
De Hatten, Xavier; Asil, Demet; Friend, Richard H.; Nitschke, Jonathan R.
Journal of the American Chemical Society, 2012 , vol. 134, # 46 p. 19170 - 19178
反应条件
1.1: sulfuric acid; nitric acid / 16 h / 20 - 100 °C 2.1: sodium hydride / ethylene glycol dimethyl ether; mineral oil / 1 h / 20 °C / |Inert atmosphere 2.2: 20 °C / |Inert atmosphere View Scheme
参考文献
De Hatten, Xavier; Asil, Demet; Friend, Richard H.; Nitschke, Jonathan R.
Journal of the American Chemical Society, 2012 , vol. 134, # 46 p. 19170 - 19178
